KEGG   ORTHOLOGY: K19883
Entry
K19883                      KO                                     
Symbol
aacA-aphD
Name
bifunctional aminoglycoside 6'-N-acetyltransferase / aminoglycoside 2''-phosphotransferase [EC:2.3.1.82 2.7.1.190]
Reaction
R11229  GTP:gentamicin-C 2''-O-phosphotransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19883  aacA-aphD; bifunctional aminoglycoside 6'-N-acetyltransferase / aminoglycoside 2''-phosphotransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.82  aminoglycoside 6'-N-acetyltransferase
     K19883  aacA-aphD; bifunctional aminoglycoside 6'-N-acetyltransferase / aminoglycoside 2''-phosphotransferase
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.190  aminoglycoside 2''-phosphotransferase
     K19883  aacA-aphD; bifunctional aminoglycoside 6'-N-acetyltransferase / aminoglycoside 2''-phosphotransferase
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  Aminoglycoside resistance genes
   N-Acetyltransferases
    K19883  aacA-aphD; bifunctional aminoglycoside 6'-N-acetyltransferase / aminoglycoside 2''-phosphotransferase
   O-Phosphotransferases
    K19883  aacA-aphD; bifunctional aminoglycoside 6'-N-acetyltransferase / aminoglycoside 2''-phosphotransferase
Other DBs
COG: COG1670
GO: 0047663
Genes
SAV: SAVP026(aacA)
SAH: SaurJH1_2806
SAJ: SaurJH9_2761
SUK: SAA6008_01993
SUW: SATW20_20700(aacA-aphD)
SAUZ: SAZ172_2086
SAUR: SABB_05319
SER: SERP1585(aacA)
SHA: SH1611(aacAaphD)
SHH: ShL2_01559
SSD: SPSINT_1483
SSCZ: RN70_01460
MLEN: H3V22_01730 H3V22_14150(aph(2'')-Ia)
MCL: MCCL_plsB0041
SMB: smi_1704(aacA-aphD)
SPAB: KQ224_01955 KQ224_03370
EFA: EFA0061
EAV: EH197_00430(aph(2'')-Ia)
VLU: M2919_02100(aph(2'')-Ia)
VG: 26797625(aacA-aphD)
AG: AAA26865(aac(6')-aph(2''))
 » show all
Reference
PMID:3015884
  Authors
Ferretti JJ, Gilmore KS, Courvalin P
  Title
Nucleotide sequence analysis of the gene specifying the bifunctional 6'-aminoglycoside acetyltransferase 2"-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activities.
  Journal
J Bacteriol 167:631-8 (1986)
DOI:10.1128/JB.167.2.631-638.1986
  Sequence
[ag:AAA26865]
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