KEGG   ORTHOLOGY: K20592
Entry
K20592            Tight     KO                                     
Symbol
genN
Name
SAM-dependent 3''-N-methyltransferase [EC:2.1.1.-]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R11292  S-adenosyl-L-methionine:3''-dehydro-3''-amino-gentamicin-A2 N-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20592  genN; SAM-dependent 3''-N-methyltransferase
Other DBs
COG: COG2890
Genes
AG: CAF31454(genN)
Reference
PMID:26946376
  Authors
Ni X, Zong T, Zhang H, Gu Y, Huang M, Tian W, Xia H
  Title
Biosynthesis of 3''-demethyl-gentamicin C components by genN disruption strain of Micromonospora echinospora and test their antimicrobial activities in vitro.
  Journal
Microbiol Res 185:36-44 (2016)
DOI:10.1016/j.micres.2016.01.005
  Sequence
[ag:CAF31454]
Reference
PMID:25641167
  Authors
Huang C, Huang F, Moison E, Guo J, Jian X, Duan X, Deng Z, Leadlay PF, Sun Y
  Title
Delineating the biosynthesis of gentamicin x2, the common precursor of the gentamicin C antibiotic complex.
  Journal
Chem Biol 22:251-61 (2015)
DOI:10.1016/j.chembiol.2014.12.012
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