KEGG   ORTHOLOGY: K21191
Entry
K21191                      KO                                     
Symbol
mdpB2
Name
CoA ligase [EC:6.2.1.-]
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00829  3,6-Dimethylsalicylyl-CoA biosynthesis, malonyl-CoA => 6-methylsalicylate => 3,6-dimethylsalicylyl-CoA
Reaction
R11370  6-methylsalicylate:CoA ligase (AMP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21191  mdpB2; CoA ligase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21191  mdpB2; CoA ligase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K21191  mdpB2; CoA ligase
Other DBs
COG: COG1021
Genes
SGM: GCM10017557_73710(dhbE)
STUB: MMF93_33245
ACTI: UA75_18045
ACAD: UA74_17520
ACTA: C1701_26455
VMA: VAB18032_24835
CCAZ: COUCH_15995
AG: ABY66018(mdpB2)
Reference
PMID:17918933
  Authors
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B
  Title
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.
  Journal
J Am Chem Soc 129:13082-94 (2007)
DOI:10.1021/ja073275o
  Sequence
[ag:ABY66018]
Reference
PMID:20718468
  Authors
Ling J, Horsman GP, Huang SX, Luo Y, Lin S, Shen B
  Title
Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate.
  Journal
J Am Chem Soc 132:12534-6 (2010)
DOI:10.1021/ja1050814
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