KEGG   ORTHOLOGY: K21295
Entry
K21295                      KO                                     
Symbol
AF510
Name
5-dehydro-6-demethoxyfumagillol synthase [EC:1.14.14.184]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00969  Fumagillin biosynthesis, farnesyl-PP => fumagillin
Reaction
R13117  (+)-exo-beta-bergamotene,[reduced NADPH---hemoprotein reductase] oxidoreductase (5-dehydro-6-demethoxyfumagillol-producing)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K21295  AF510; 5-dehydro-6-demethoxyfumagillol synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.184  5-dehydro-6-demethoxyfumagillol synthase
     K21295  AF510; 5-dehydro-6-demethoxyfumagillol synthase
Other DBs
COG: COG2124
Genes
MAJ: MAA_08345
PCHM: VFPPC_11136
AMUS: LMH87_004137
SAPO: SAPIO_CDS8525
AFM: AFUA_8G00510
PFJ: MYCFIDRAFT_201210
Reference
PMID:24568283
  Authors
Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y
  Title
Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.
  Journal
J Am Chem Soc 136:4426-36 (2014)
DOI:10.1021/ja500881e
  Sequence
[afm:AFUA_8G00510]
LinkDB

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