KEGG   ORTHOLOGY: K21723
Entry
K21723                      KO                                     
Symbol
ndmB
Name
methylxanthine N3-demethylase [EC:1.14.13.179]
Pathway
map00232  Caffeine metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
Module
M00915  Caffeine degradation, caffeine => xanthine
Reaction
R07939  caffeine:oxygen oxidoreductase (N3-demethylating)
R07954  caffeine:oxygen oxidoreductase (N3-demethylating)
R07961  theobromine:oxygen oxidoreductase (N3-demethylating)
R07962  theobromine:oxygen oxidoreductase (N3-demethylating)
R07967  3-methylxanthine:oxygen oxidoreductase (N3-demethylating)
R07968  3-methylxanthine:oxygen oxidoreductase (N3-demethylating)
R07975  theophylline:oxygen oxidoreductase (N3-demethylating)
R07976  theophylline:oxygen oxidoreductase (N3-demethylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K21723  ndmB; methylxanthine N3-demethylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.179  methylxanthine N3-demethylase
     K21723  ndmB; methylxanthine N3-demethylase
Other DBs
COG: COG4638
Genes
PHF: NLY38_11715
PCAF: DSC91_007650
PPAI: E1956_21975
MMS: mma_0224
PAEZ: PAE61_02340
PARH: I5S86_05110
AG: AFD03117(ndmB)
Reference
PMID:22328667
  Authors
Summers RM, Louie TM, Yu CL, Gakhar L, Louie KC, Subramanian M
  Title
Novel, highly specific N-demethylases enable bacteria to live on caffeine and related purine alkaloids.
  Journal
J Bacteriol 194:2041-9 (2012)
DOI:10.1128/JB.06637-11
  Sequence
[ag:AFD03117]
LinkDB

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