Entry
Symbol
STOX, DBOX
Name
tetrahydroprotoberberine oxidase [EC:
1.3.3.8 ]
Pathway
map00950 Isoquinoline alkaloid biosynthesis
map01110 Biosynthesis of secondary metabolites
Module
M00945 Sanguinarine biosynthesis, (S)-reticuline => sanguinarine
Reaction
R02880 (S)-tetrahydroberberine:oxigen oxidoreductase
R03722 (S)-tetrahydrocolumbamine:oxigen oxidoreductase
R04703 dihydrosanguinarine:oxygen oxidoreductase
R08795 tetrahydropalmatine:oxygen oxidoreductase
R11748 (S)-tetrahydropapaverine:oxygen oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09110 Biosynthesis of other secondary metabolites
00950 Isoquinoline alkaloid biosynthesis
K22089 STOX, DBOX; tetrahydroprotoberberine oxidase
Enzymes [BR:ko01000 ]
1. Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.3 With oxygen as acceptor
1.3.3.8 tetrahydroberberine oxidase
K22089 STOX, DBOX; tetrahydroprotoberberine oxidase
BRITE hierarchy
Other DBs
Genes
Taxonomy UniProt
Reference
Authors
Hagel JM, Beaudoin GA, Fossati E, Ekins A, Martin VJ, Facchini PJ
Title
Characterization of a flavoprotein oxidase from opium poppy catalyzing the final steps in sanguinarine and papaverine biosynthesis.
Journal
Sequence
Reference
Authors
Gesell A, Chavez ML, Kramell R, Piotrowski M, Macheroux P, Kutchan TM
Title
Heterologous expression of two FAD-dependent oxidases with (S)-tetrahydroprotoberberine oxidase activity from Arge mone mexicana and Berberis wilsoniae in insect cells.
Journal
Sequence
LinkDB
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