KEGG ORTHOLOGY: K22099

KEGG

ORTHOLOGY: K22099

Entry

K22099                      KO

Symbol

folC2

Name

dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]

Pathway

Folate biosynthesis

Metabolic pathways

Biosynthesis of cofactors

Module

Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF

Reaction

tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming)

7,8-dihydropteroate:L-glutamate ligase (ADP-forming)

tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K22099  folC2; dihydrofolate synthase / folylpolyglutamate synthase
Enzymes [BR:ko01000]
6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.12  dihydrofolate synthase
     K22099  folC2; dihydrofolate synthase / folylpolyglutamate synthase
    6.3.2.17  tetrahydrofolate synthase
     K22099  folC2; dihydrofolate synthase / folylpolyglutamate synthase

Other DBs

COG:

GO:	0008841 0004326

Genes

CTR:

CTD:	CTDEC_0611

CTF:	CTDLC_0611

CTRD:

CTRO:

CTRT:

CTA:

CTY:

CRA:

CTRQ:

CTRX:

CTRZ:

CTRP:

CTLJ:

CTLX:

CTLL:

CTB:

CTRR:

CTLF:

CTLI:

CTLINITIAL_04565

CTL:	CTLon_0869

CTRU:

CTRL:

CTRV:

CTRM:

CTLA:

CTLM:

CTLS:

CTLZ:

CTLC:

CTLN:

CTLB:

CTLQ:

CTO:

CTRN:

CTJ:

CTZ:

CTG:	E11023_03210

CTK:	E150_03230

CSW:

CES:

CTRB:

CTRE:

CTRS:

CTEC:

CFS:

CFW:

CTFW:

CTRF:

CTCH:

CTN:	G11074_03210

CTQ:	G11222_03230

CTV:	CTG9301_03225

CTW:	G9768_03210

CTRG:

CTRI:

CTRA:

CTRH:

CTRJ:

CTRK:

CTJT:

CTCF:

CTFS:

CTHF:

CTCJ:

CTHJ:

CTMJ:

CTTJ:

CTJS:

CTRC:

CTRW:

CTRY:

CTCT:

CMU:

CMUR:

CMN:	BB17_04830

CMM:	NC80_04550

CMG:	NC81_04570

CMX:

CMZ:

CPN:

CPA:

CPJ:	CPj0760(CPj0760)

CPT:

CLP:	CPK_ORF00166

CHP:	CPSIT_1057

CHB:

CHS:	CPS0A_1080

CHI:	CPS0B_1065

CHT:	CPS0D_1075

CHC:	CPS0C_1075

CHR:

CPSC:

CPSN:

CPSB:

CPSG:

CPSM:

CPSI:

CPSV:

CPSW:

CPST:

CPSD:

CPSA:

CAV:	M832_07830

CCA:

CAB:

CABO:

CFE:	CF0016(oxr1)

CGZ:	M787_001830

CHLA:

CSUI:

Chls_964(alternative_Folylglutamate_Synthase)

CBUE:

CSEE:

CCRD:

CPAA:

Reference

Authors

Adams NE, Thiaville JJ, Proestos J, Juarez-Vazquez AL, McCoy AJ, Barona-Gomez F, Iwata-Reuyl D, de Crecy-Lagard V, Maurelli AT

Title

Promiscuous and adaptable enzymes fill "holes" in the tetrahydrofolate pathway in Chlamydia species.

Journal

MBio 5:e01378-14 (2014)
DOI:10.1128/mBio.01378-14

Reference

Authors

Stephens RS, Kalman S, Lammel C, Fan J, Marathe R, Aravind L, Mitchell W, Olinger L, Tatusov RL, Zhao Q, Koonin EV, Davis RW.

Title

Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis.

Journal

Science 282:754-9 (1998)
DOI:10.1126/science.282.5389.754

Sequence

[ctr:CT_611]

LinkDB

DBGET integrated database retrieval system