KEGG   ORTHOLOGY: K22271
Entry
K22271            Tight     KO                                     
Symbol
Core
Name
Hepatitis C virus core protein
Pathway
map03230  Viral genome structure
map05160  Hepatitis C
map05203  Viral carcinogenesis
Network
nt06163  Hepatitis C virus (HCV)
nt06222  IFN signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06516  TNF signaling
nt06517  TLR signaling
nt06524  Apoptosis
  Element
N00269  HCV core to TNF-NFKB signaling pathway
N00270  HCV Core to IFN signaling pathway
N00518  HCV Core to ERK signaling pathway
N00519  HCV Core to ERK signaling pathway
N00521  HCV Core to p21-cell cycle G1/S
N00523  HCV Core to p21-cell cycle G1/S
N00527  HCV Core to crosstalk between extrinsic and intrinsic apoptotic pathways
N00528  HCV core to extrinsic apoptotic pathway
N00529  HCV core to RXRA/PPARA-mediated transcription
N00530  HCV core to RXRA/LXRA-mediated transcription
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22271  Core; Hepatitis C virus core protein
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K22271  Core; Hepatitis C virus core protein
  09172 Infectious disease: viral
   05160 Hepatitis C
    K22271  Core; Hepatitis C virus core protein
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22271  Core; Hepatitis C virus core protein
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Hepatitis C virus (Hepacivirus C)
   K22271  Core; Hepatitis C virus core protein
Genes
VP: 951475-1(p21)
Reference
PMID:23490391
  Authors
Gouklani H, Beyer C, Drummer H, Gowans EJ, Netter HJ, Haqshenas G
  Title
Identification of specific regions in hepatitis C virus core, NS2 and NS5A that genetically interact with p7 and co-ordinate infectious virus production.
  Journal
J Viral Hepat 20:e66-71 (2013)
DOI:10.1111/jvh.12004
  Sequence
[vp:951475-1]
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
LinkDB

KEGG   Homo sapiens (human): 10197
Entry
10197             CDS       T01001                                 
Symbol
PSME3, HEL-S-283, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA
Name
(RefSeq) proteasome activator subunit 3
  KO
K06698  proteasome activator subunit 3 (PA28 gamma)
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa04612  Antigen processing and presentation
hsa05160  Hepatitis C
Network
nt06163  Hepatitis C virus (HCV)
nt06263  Hepatocellular carcinoma
  Element
N00530  HCV core to RXRA/LXRA-mediated transcription
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    10197 (PSME3)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    10197 (PSME3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    10197 (PSME3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    10197 (PSME3)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    10197 (PSME3)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA28 (11S REG)
    10197 (PSME3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   10197 (PSME3)
SSDB
Motif
Pfam: PA28_beta PA28_alpha
Other DBs
NCBI-GeneID: 10197
NCBI-ProteinID: NP_005780
OMIM: 605129
HGNC: 9570
Ensembl: ENSG00000131467
UniProt: P61289 V9HWJ8
Structure
LinkDB
Position
17:42833397..42843760
AA seq 254 aa
MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHS
DMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIE
KVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQIS
RYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIE
KIKRPRSSNAETLY
NT seq 765 nt   +upstreamnt  +downstreamnt
atggcctcgttgctgaaggtggatcaggaagtgaagctcaaggttgattctttcagggag
cggatcacaagtgaggcagaagacttggtggcaaattttttcccaaagaagttattagaa
cttgatagttttctgaaggaaccaatcttaaacatccatgacctaactcagatccactct
gacatgaatctcccagtccctgaccccattcttctcaccaatagccatgatggactggat
ggtcccacttataagaagcgaaggttggatgagtgtgaagaagccttccaaggaaccaag
gtgtttgtgatgcccaatgggatgctgaaaagcaaccagcagctggtggacattattgag
aaagtgaaacctgagatccggctgttgattgagaaatgtaacacggtcaaaatgtgggta
cagctcctgattcccaggatagaagatggaaacaactttggggtgtccattcaggaggaa
acagttgcagagctaagaactgttgagagtgaagctgcatcttatctggaccagatttct
agatattatattacaagagccaaattggtttctaaaatagctaaatatccccatgtggag
gactatcgccgcaccgtgacagagattgatgagaaagaatatatcagccttcggctcatc
atatcagagctgaggaatcaatatgtcactctacatgacatgatcctgaaaaatatcgag
aagatcaaacggccccggagcagcaatgcagagactctgtactga

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