KEGG   ORTHOLOGY: K22571
Entry
K22571                      KO                                     
Symbol
AF390-400, fmaD
Name
5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase [EC:2.1.1.387]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00969  Fumagillin biosynthesis, farnesyl-PP => fumagillin
Reaction
R13123  S-adenosyl-L-methionine:5-dehydro-6-demethoxy-6-hydroxyfumagillol 6-O-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K22571  AF390-400, fmaD; 5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.387  5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase
     K22571  AF390-400, fmaD; 5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase
Genes
MAJ: MAA_08362
PCHM: VFPPC_11120
SAPO: SAPIO_CDS8519
AFM: AFUA_8G00390 AFUA_8G00400
NFI: NFIA_093930
Reference
  Authors
Lin HC, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y
  Title
Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway.
  Journal
J Am Chem Soc 136:4426-36 (2014)
DOI:10.1021/ja500881e
  Sequence
LinkDB

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