KEGG   ORTHOLOGY: K23109
Entry
K23109                      KO                                     
Symbol
fldH
Name
aromatic 2-oxoacid reductase [EC:1.1.1.110]
Pathway
map00350  Tyrosine metabolism
map00360  Phenylalanine metabolism
map00380  Tryptophan metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R01370  phenyllactate:NAD+ oxidoreductase
R03337  (R)-3-(4-hydroxyphenyl)lactate:NAD+ 2-oxidoreductase
R12256  (R)-(indol-3-yl)lactate:NAD+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K23109  fldH; aromatic 2-oxoacid reductase
   00360 Phenylalanine metabolism
    K23109  fldH; aromatic 2-oxoacid reductase
   00380 Tryptophan metabolism
    K23109  fldH; aromatic 2-oxoacid reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.110  aromatic 2-oxoacid reductase
     K23109  fldH; aromatic 2-oxoacid reductase
Other DBs
COG: COG1052
GO: 0097256
Genes
MSUT: LC048_24585
CBO: CBO3284(fldH)
CBA: CLB_3340(ldhA-2)
CBH: CLC_3226(ldhA-2)
CBY: CLM_3717(ldhA)
CBL: CLK_2700
CBB: CLD_1239
CBI: CLJ_B3564
CBF: CLI_3454(ldhA-2)
CBM: CBF_3436(ldhA-2)
CBJ: H04402_03369
CLD: CLSPO_c34040(fldH)
CCAA: KQH81_13535
NBJ: HXK95_000970
 » show all
Reference
PMID:10849007
  Authors
Dickert S, Pierik AJ, Linder D, Buckel W
  Title
The involvement of coenzyme A esters in the dehydration of (R)-phenyllactate to (E)-cinnamate by Clostridium sporogenes.
  Journal
Eur J Biochem 267:3874-84 (2000)
DOI:10.1046/j.1432-1327.2000.01427.x
  Sequence
[cld:CLSPO_c34040]
Reference
PMID:29168502
  Authors
Dodd D, Spitzer MH, Van Treuren W, Merrill BD, Hryckowian AJ, Higginbottom SK, Le A, Cowan TM, Nolan GP, Fischbach MA, Sonnenburg JL
  Title
A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites.
  Journal
Nature 551:648-652 (2017)
DOI:10.1038/nature24661
  Sequence
[cld:CLSPO_c34040]
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