KEGG   ORTHOLOGY: K23999
Entry
K23999                      KO                                     
Symbol
fom1
Name
phosphoenolpyruvate phosphomutase / 2-hydroxyethylphosphonate cytidylyltransferase [EC:5.4.2.9 2.7.7.104]
Pathway
map00440  Phosphonate and phosphinate metabolism
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00903  Fosfomycin biosynthesis, phosphoenolpyruvate => fosfomycin
Reaction
R00661  phosphoenolpyruvate 2,3-phosphonomutase
R12498  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K23999  fom1; phosphoenolpyruvate phosphomutase / 2-hydroxyethylphosphonate cytidylyltransferase
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K23999  fom1; phosphoenolpyruvate phosphomutase / 2-hydroxyethylphosphonate cytidylyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.104  2-hydroxyethylphosphonate cytidylyltransferase
     K23999  fom1; phosphoenolpyruvate phosphomutase / 2-hydroxyethylphosphonate cytidylyltransferase
 5. Isomerases
  5.4  Intramolecular transferases
   5.4.2  Phosphotransferases (phosphomutases)
    5.4.2.9  phosphoenolpyruvate mutase
     K23999  fom1; phosphoenolpyruvate phosphomutase / 2-hydroxyethylphosphonate cytidylyltransferase
Other DBs
COG: COG2513 COG0615
GO: 0050188
Genes
PMAW: MACH26_33050
OSG: BST96_06905
MPRF: J8N69_05410(aepX)
PHN: PAEH1_00300
MEU: ACJ67_08960
AZO: azo2698(pepM)
AOA: dqs_2833
ECOG: FIV45_08000(aepX)
SNEA: NBZ79_03295(aepX)
HCP: HCN_1062
HCB: HCBAA847_0912
HWI: A0Z60_07480(aepX)
CHYO: CHH_1593
CHW: A2J15_004815(aepX)
CINF: CINF_1344
AFC: AFAEC_0069 AFAEC_0075
ANT: Arnit_2943
NSA: Nitsa_1412
DLM: DPPLL_12490
DAK: DaAHT2_1860
DAL: Dalk_1323
CTC: CTC_01698
CTET: BN906_01840
CBJ: H04402_02796
CBE: Cbei_4338
CBZ: Cbs_4338
CBEI: LF65_04862
CSR: Cspa_c46190(ppm)
CSB: CLSA_c08730(ppm)
CBUT: ATN24_05940
CARG: RSJ17_12820
CDY: F3K33_22185(aepX)
CCAA: KQH81_02885(aepX)
CNN: CNEO_1087(ppm)
CGEL: psyc5s11_47370
HHJ: NQ487_01265(aepX) NQ487_01315(aepX)
RAL: Rumal_1340
ALAC: JYE50_12220(aepX) JYE50_12300(aepX)
AHC: JYE49_12525(aepX)
BPEN: NQ488_09095(aepX)
CBAF: JS518_12300(aepX) JS518_12380(aepX)
RIX: RO1_19910
RRK: H8S51_002390(aepX)
CLE: Clole_3577
HAS: Halsa_0038
SSG: Selsp_0338
SELE: ADJ74_04700
SELO: AXE86_05255
SELT: BCS37_10905
SDIA: QU667_11285(aepX)
LCG: L3BBH23_02720
OLS: Olsu_0594
TES: BW730_00185
SAIU: J4H86_04280(aepX)
NHY: JQS43_02325(aepX)
SNA: Snas_5665
NAV: JQS30_13655(aepX)
AYM: YM304_30130
ARP: NIES39_A00310
ELUT: CKA38_13745(aepX)
TDE: TDE_1413
TBE: Trebr_0279
TPI: TREPR_2364
TPK: JO40_09715
TPHG: FUT81_06855(aepX)
TRI: DYE50_04590(aepX)
TPAV: HRQ91_06190(aepX)
TSK: HRI97_05665(aepX)
BPAA: K7I13_01580(aepX)
HPRI: P0082_09550(aepX)
SBU: SpiBuddy_0272
SGP: SpiGrapes_1560
TAZ: TREAZ_2217
SCD: Spica_1331
BHC: JFL75_01540(aepX)
FSU: Fisuc_0993
FSC: FSU_1439
BTH: BT_1720
BTHO: Btheta7330_01295(pphA)
BFR: BF1832 BF2578
BFS: BF9343_1814(aepX)
BFG: BF638R_1867
BUN: Bun01g_29040
BEG: INE88_02862
BSTE: K6V31_00385(aepX)
BDO: EL88_10435
PCOI: LK433_14490(aepX)
DRC: G0Q07_19260(aepX)
RCG: N7E81_15220(aepX)
FAX: FUAX_43910
NLI: G3M70_12635(aepX)
NVA: G3M78_13645(aepX)
METB: AW729_03845
TAR: TALC_00083
LOB: NEF87_004219
PSYT: DSAG12_01622(ribL_1)
ARG: QT11_C0001G0509
AG: BAA32495(fom1)
 » show all
Reference
PMID:28727444
  Authors
Cho SH, Kim SY, Tomita T, Shiraishi T, Park JS, Sato S, Kudo F, Eguchi T, Funa N, Nishiyama M, Kuzuyama T
  Title
Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme.
  Journal
ACS Chem Biol 12:2209-2215 (2017)
DOI:10.1021/acschembio.7b00419
  Sequence
[ag:BAA32495]
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