KEGG ORTHOLOGY: K24418

ORTHOLOGY: K24418

Entry

K24418                      KO

Symbol

METTL5

Name

rRNA N6-adenosine-methyltransferase METTL5

Disease

H00768

Autosomal recessive intellectual developmental disorder

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03009 Ribosome biogenesis
    K24418  METTL5; rRNA N6-adenosine-methyltransferase METTL5
Ribosome biogenesis [BR:ko03009]
Eukaryotic type
  Pre-40S particles
   Export and cytoplasmic maturation factors
    K24418  METTL5; rRNA N6-adenosine-methyltransferase METTL5

Genes

HSA:	29081(METTL5)

PTR:	100613773(METTL5)

PPS:	100978958(METTL5)

GGO:	101134423(METTL5)

PON:	100172489(METTL5)

NLE:	100585074(METTL5)

HMH:	116810688(METTL5)

MCC:	707119(METTL5)

MCF:	102144548(METTL5)

MTHB:

126932540 126947769

MNI:	105483271(METTL5)

CSAB:

103217279(METTL5)

CATY:

105579771(METTL5)

PANU:

101013640(METTL5)

TGE:	112636388(METTL5)

MLEU:

105545281(METTL5)

RRO:	104655048(METTL5)

RBB:	108516841(METTL5) 108539686

TFN:	117064441 117064758 117094885(METTL5)

PTEH:

111535194(METTL5)

CANG:

105513372 105514512(METTL5)

CJC:	100396904(METTL5)

SBQ:	101040181(METTL5)

CIMI:

108295263(METTL5)

CSYR:

103260788(METTL5)

MMUR:

105880700(METTL5)

LCAT:

123643271(METTL5)

PCOQ:

105815603(METTL5)

OGA:	100956870(METTL5)

MMU:	75422(Mettl5)

MCAL:

110285923(Mettl5)

MPAH:

110317751(Mettl5)

RNO:	502632(Mettl5)

MCOC:

116090278(Mettl5)

ANU:	117703100(Mettl5)

MUN:	110547788(Mettl5)

CGE:	100765596(Mettl5)

MAUA:

101838972(Mettl5)

PROB:

127222439(Mettl5)

PLEU:

114701798(Mettl5)

MORG:

121433202(Mettl5)

MFOT:

126488435

AAMP:

119818914(Mettl5)

NGI:	103737978(Mettl5)

HGL:	101723651(Mettl5)

CPOC:

100736160(Mettl5)

CCAN:

109681841(Mettl5)

DORD:

105995544(Mettl5)

DSP:	122120059(Mettl5)

PLOP:

125350575(Mettl5)

NCAR:

124980742

MMMA:

107136912(Mettl5)

OCU:

100343718

OPI:	101534345(METTL5)

TUP:	102477747(METTL5)

GVR:	103606947(METTL5)

CFA:	478788(METTL5)

CLUD:

112668068(METTL5)

VVP:	112916427(METTL5)

VLG:	121471873(METTL5)

NPO:	129498416(METTL5)

AML:	100471841(METTL5)

UMR:	103659546(METTL5)

UAH:	113250795(METTL5)

UAR:	123780935(METTL5)

ELK:

111141118

LLV:

125095693

MPUF:

101673536(METTL5)

MNP:	132013818(METTL5)

MLK:	131827117(METTL5)

NVS:	122902577(METTL5)

ORO:	101367231(METTL5)

EJU:	114224381(METTL5)

ZCA:	113919464(METTL5)

MLX:	118012346(METTL5)

NSU:	110592359(METTL5)

LWW:	102732179(METTL5)

FCA:	101087766(METTL5)

PYU:	121030675(METTL5)

PCOO:

112870486(METTL5)

PBG:	122481436(METTL5)

PVIV:

125172676(METTL5)

LRUF:

124515522

PTG:	102967259(METTL5)

PPAD:

109272729(METTL5)

PUC:

125911562

AJU:

106987720

HHV:	120242849(METTL5)

BTA:	614427(METTL5)

BOM:	102272137(METTL5)

BIU:	109566625(METTL5)

BBUB:

102394155(METTL5)

BBIS:

104995518(METTL5)

CHX:	102169228(METTL5)

OAS:	101118588(METTL5) 114113591 114114080

BTAX:

128061723(METTL5)

ODA:	120854903(METTL5)

CCAD:

122446380 122453732(METTL5)

MBEZ:

129538222(METTL5)

SSC:	100520407(METTL5)

CFR:	102504325(METTL5)

CBAI:

105081992(METTL5)

CDK:	105091076(METTL5)

VPC:	102536028(METTL5)

BACU:

103008935(METTL5)

BMUS:

118898178(METTL5) 118901943

LVE:	103081214(METTL5)

OOR:	101272787 101286602(METTL5)

DLE:	111172845(METTL5)

PCAD:

102986169(METTL5)

PSIU:

116756943(METTL5) 116760300

NASI:

112405964(METTL5)

ECB:	100052812(METTL5)

EPZ:	103558008(METTL5)

EAI:	106843631(METTL5)

MYB:	102252628(METTL5)

MYD:	102753691(METTL5)

MMYO:

118661311(METTL5)

MLF:	102435375(METTL5)

PKL:	118709299(METTL5)

EFUS:

103283336(METTL5)

MNA:	107528910(METTL5)

DRO:	112305794(METTL5)

SHON:

118975895 118985724(METTL5)

AJM:	119045835(METTL5)

PDIC:

114494123(METTL5)

PHAS:

123809690(METTL5)

MMF:	118625160(METTL5)

PPAM:

129061737(METTL5)

HAI:	109390413(METTL5)

RFQ:	117025840(METTL5) 117037050

PALE:

102878594(METTL5)

PGIG:

120597209(METTL5)

PVP:	105290579(METTL5)

RAY:	107521055(METTL5)

MJV:	108406344(METTL5)

TOD:	119253876 119255914(METTL5) 119255933

SARA:

101554356(METTL5)

SETR:

126009139(METTL5)

LAV:	100666992(METTL5)

TMU:

101348680

ETF:	101640787(METTL5)

DNM:	101422865(METTL5)

MDO:	100024458(METTL5)

GAS:	123242221(METTL5)

SHR:	100926991(METTL5)

AFZ:

127554565

PCW:	110211553(METTL5)

OAA:	100077587(METTL5)

GGA:	771367(METTL5)

PCOC:

116232883(METTL5)

MGP:	100541514(METTL5)

CJO:	107316688(METTL5)

TPAI:

128076809(METTL5)

LMUT:

125692566 125696863(METTL5)

NMEL:

110399922(METTL5)

APLA:

101794426(METTL5)

ACYG:

106029978(METTL5)

CATA:

118260604(METTL5)

AFUL:

116490701(METTL5)

TGU:	100190368(METTL5)

LSR:	110472776(METTL5)

SCAN:

103814422(METTL5)

PMOA:

120500168(METTL5)

OTC:	121335536(METTL5)

PRUF:

121356430(METTL5)

GFR:	102044671(METTL5)

FAB:	101816761(METTL5)

OMA:	130266607(METTL5)

PHI:	102113982(METTL5)

PMAJ:

107207481(METTL5)

CCAE:

111932108(METTL5)

CCW:	104693895(METTL5)

CBRC:

103616578(METTL5)

ETL:	114073768(METTL5)

ZAB:	102065201(METTL5)

ZLE:	135450399(METTL5)

ACHL:

103808565(METTL5)

SVG:	106855493(METTL5)

MMEA:

130576789(METTL5)

HRT:	120754864(METTL5)

FPG:	101922188(METTL5)

FCH:	102048157(METTL5)

CLV:	102095308(METTL5)

EGZ:	104128046(METTL5)

NNI:	104009991(METTL5)

PCRI:

104025335(METTL5)

PLET:

104624828(METTL5)

EHS:	104504515(METTL5)

PCAO:

104040108(METTL5)

ACUN:

113481990(METTL5)

TALA:

104366391(METTL5)

PADL:

103918166(METTL5)

AFOR:

103898316(METTL5)

ACHC:

115343247(METTL5)

HALD:

104322397(METTL5)

HLE:	104831466(METTL5)

AGEN:

126041859

GCL:

127018566

CCRI:

104163627(METTL5)

CSTI:

104556095(METTL5)

CMAC:

104474394(METTL5)

MUI:	104540252(METTL5)

BREG:

104639377(METTL5)

FGA:	104076121(METTL5)

GSTE:

104251988(METTL5)

LDI:	104345169(METTL5)

MNB:	103773540(METTL5)

OHA:	104328981(METTL5)

NNT:	104400058(METTL5)

SHAB:

115608006(METTL5)

DPUB:

104304718(METTL5)

PGUU:

104471523(METTL5)

ACAR:

104520934(METTL5)

CPEA:

104387381(METTL5)

AVIT:

104268325(METTL5)

CVF:	104294894(METTL5)

RTD:	128913016(METTL5)

CUCA:

104054552(METTL5)

TEO:	104370580(METTL5)

BRHI:

104499021(METTL5)

AAM:	106499199(METTL5)

AROW:

112963925(METTL5)

NPD:	112953983(METTL5)

TGT:	104570470(METTL5)

DNE:	112979384(METTL5)

SCAM:

104138267(METTL5)

ASN:	102383621(METTL5)

AMJ:	102570259(METTL5)

CPOO:

109322655(METTL5)

GGN:	109301547(METTL5)

PSS:	102452809(METTL5)

CMY:	102932723(METTL5)

CCAY:

125645113(METTL5)

DCC:	119863842(METTL5)

CPIC:

101952126(METTL5)

CABI:

116819383(METTL5)

MRV:	120375018(METTL5)

ACS:	100558495(mettl5)

ASAO:

132776774(METTL5)

PVT:	110076878(METTL5)

SUND:

121916435(METTL5)

PBI:	103064544(METTL5)

PMUR:

107290301(METTL5)

CTIG:

120318123(METTL5)

TSR:	106544261(METTL5)

PGUT:

117671272(METTL5)

APRI:

131202199(METTL5)

PTEX:

113434088(METTL5)

NSS:	113423596(METTL5)

VKO:	123017006(METTL5)

PMUA:

114607188(METTL5)

PRAF:

128398682(METTL5)

ZVI:	118094919(METTL5)

HCG:	128331666(METTL5)

GJA:	107119682(METTL5)

STOW:

125426038(METTL5)

EMC:	129324103(METTL5)

XLA:	734984(mettl5.L)

XTR:	595055(mettl5)

NPR:	108785506(METTL5)

RTEM:

120944032(METTL5)

BBUF:

121008165(METTL5)

MUO:	115458836 115473803(METTL5)

GSH:	117360435(METTL5)

DRE:	449776(mettl5)

SRX:	107739664 107744838

SANH:

107656520(mettl5)

SGH:

107596565

CAUA:

113052958(mettl5) 113109301

CGIB:

127964609 128020085

PTET:

122352162(mettl5)

LROH:

127171326(mettl5)

OMC:	131547551(mettl5)

PPRM:

120486954(mettl5)

RKG:	130105455(mettl5)

MAMB:

125270718(mettl5)

CIDE:

127518592

MASI:

127447633 127448040

TROS:

130555869(mettl5)

TDW:	130428081(mettl5)

MANU:

129451958(mettl5)

IPU:	100528533(mettl5)

IFU:	128608997(mettl5)

PHYP:

113526130(mettl5)

SMEO:

124379153(mettl5)

TFD:	113654282(mettl5)

TVC:	132850316(mettl5)

TRN:	134324339(mettl5)

AMEX:

103041316(mettl5)

CMAO:

118807042(mettl5)

EEE:	113584293(mettl5)

CHAR:

122131668(mettl5)

TRU:	101068807(mettl5)

TFS:	130537572(mettl5)

TNG:	GSTEN00038058G001

LCO:	104931030(mettl5)

NCC:	104948277(mettl5)

TBEN:

117480988(mettl5)

CGOB:

115026156(mettl5)

PGEO:

117466878(mettl5)

GACU:

117544420(mettl5)

EMAC:

134867217(mettl5)

ELY:	117251560(mettl5)

EFO:	125900265(mettl5)

PLEP:

121949573(mettl5)

SLUC:

116048718(mettl5)

ECRA:

117952643(mettl5)

ESP:	116697650(mettl5)

PFLV:

114564369(mettl5)

GAT:	120833837(mettl5)

PPUG:

119228319(mettl5)

AFB:	129104493(mettl5)

CLUM:

117750968(mettl5)

PSWI:

130199781(mettl5)

MSAM:

119884529(mettl5)

SCHU:

122885021(mettl5)

CUD:	121523048(mettl5)

ALAT:

119025440(mettl5)

MZE:	101474988(mettl5)

ONL:	100704162(mettl5)

OAU:	116322928(mettl5)

OLA:	101158647(mettl5)

OML:	112155494(mettl5)

CSAI:

133445953(mettl5)

XMA:	102232704(mettl5)

XCO:	114148747(mettl5)

XHE:	116722897(mettl5)

PRET:

103458673(mettl5)

PFOR:

103134275(mettl5)

PLAI:

106955206(mettl5)

PMEI:

106923230(mettl5)

GAF:	122839663(mettl5)

PPRL:

129361456(mettl5)

CVG:	107093556(mettl5)

CTUL:

119793913(mettl5)

GMU:	124871193(mettl5)

NFU:	107390036(mettl5)

KMR:	108240710(mettl5)

ALIM:

106512873(mettl5)

NWH:	119419150(mettl5)

AOCE:

111579196(mettl5)

MCEP:

125017346(mettl5)

CSEM:

103392107(mettl5)

POV:	109631148(mettl5)

SSEN:

122765396(mettl5)

HHIP:

117754403(mettl5)

HSP:	118120364(mettl5)

PPLT:

128455433(mettl5)

SMAU:

118320545(mettl5)

LCF:

108888679

SDU:	111218830(mettl5)

SLAL:

111653067(mettl5)

XGL:	120802018(mettl5)

HCQ:	109519712(mettl5)

SSCV:

125973419

SBIA:

133512466(mettl5)

PEE:	133410918(mettl5)

PTAO:

133486895(mettl5)

BPEC:

110166593(mettl5)

MALB:

109958036(mettl5)

BSPL:

114846864(mettl5)

SJO:	128368098(mettl5)

SASA:

100195883(mettl5)

STRU:

115156033(mettl5)

OTW:	112225226(mettl5)

OMY:	110501468(mettl5)

OGO:	124043022(mettl5)

ONE:	115101357(mettl5)

OKI:	109870834(mettl5)

OKE:	118386032(mettl5)

SALP:

111959700(mettl5)

SNH:	120064398(mettl5)

CCLU:

121552345(mettl5)

ELS:	105022477(mettl5)

SFM:	108920213(mettl5)

PKI:	111852296(mettl5)

AANG:

118222807(mettl5)

LOC:	102690141(mettl5)

PSPA:

121322238(mettl5)

ARUT:

117412881 117426308

PSEX:

120531824(mettl5)

LCM:	102351673(METTL5)

CMK:	103176437(mettl5)

RTP:	109913356(mettl5)

CPLA:

122551583(mettl5)

HOC:	132817108(mettl5)

LERI:

129698770(mettl5)

PMRN:

116938569(METTL5)

LRJ:	133346069(METTL5)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115918785 584008

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG9666(Mettl5)

DER:

6543556

DSE:

6618401

DSI:	Dsimw501_GD14794(Dsim_GD14794)

DYA:	Dyak_GE19596 Dyak_GE23079

DAN:

DSR:

DPO:

DPE:

DMN:	108151963 117194902 117194931

DWI:

6643069

DGR:

6557641

DMO:	Dmoj_GI11783

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:	110681264 5575291

AALB:

109431661

ASUA:

134205354

CQU:	CpipJ_CPIJ009437

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:	105195439 120359172

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

NPT:	124218617 124223298

NFB:	124183407 124186616

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212159

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

API:	100163106 100167732

DNX:

AGS:

RMD:

ACOO:

DVT:	126904326 126909693

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128996669 129005180

PHU:	Phum_PHUM518280

FOC:

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_C38D4.9(metl-5)

CBR:

CBG_17981

CRQ:	GCK72_010023

NAI:	NECAME_12716

BMY:	BM_BM2665(Bm2665)

LOA:	LOAG_01707

TSP:

Tsp_07385

HRO:	HELRODRAFT_157302

LGI:	LOTGIDRAFT_172641

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

OED:

PMAX:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106165619 106181798

SMM:	Smp_151780

OVI:	T265_08129

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_54966

AQU:

ATH:

ALY:

CRB:

CSAT:

104717312 104721988 104730449 104765525

EUS:	EUTSA_v10026253mg

BRP:	103854070 103861855

BNA:	106375562 106386096 106399591 106409053

BOE:	106304208 106323723

RSZ:	108830980 108837168 108842503

THJ:

104804018

CPAP:

110820875

CIT:

102629466

CIC:	CICLE_v10009448mg

PVY:

MINC:

TCC:

GRA:

GHI:	107901257 107962753

GAB:

108486092

HSYR:

120126658 120144479 120156627

DZI:

EGR:

GMX:

GSJ:

PVU:	PHAVU_004G168000g

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:	131594296 131594300 131603943

LJA:	Lj2g3v0824610.1(Lj2g3v0824610.1)

ADU:

107490293

AIP:

107644405

AHF:	112751234 112778638 112802115

LANG:

109342981

PCIN:

129292136

QSA:	O6P43_007899

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

111785455 111786047 111804919

RCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107775069 107797895

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:	130757142 130789485

BVG:

104902250

SOE:

110804552

CQI:	110690985 110707740

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

Os06t0162600-01(Os06g0162600)

OBR:

OGL:

BDI:

ATS:

TDC:	119330684 119336560

TAES:

123151188 123155769 542936

TUA:

125521530

LPER:

127318110

LRD:	124684856 124685087

SBI:

8070869

ZMA:	100191332 103629523

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:

ZOF:	121992627 121993929 121996588

DCT:

110092170

PEQ:

110021237

AOF:

109840066

MSIN:

131223024 131224292 131230519 131248201

NCOL:

116245920

ATR:

18426702

SMO:	SELMODRAFT_110107 SELMODRAFT_235018

PPP:

112283441

CRE:	CHLRE_08g384700v5

VCN:	VOLCADRAFT_106378

MNG:	MNEG_11877

CSL:	COCSUDRAFT_60120

CVR:	CHLNCDRAFT_138547

APRO:

F751_4019

OLU:	OSTLU_89455

OTA:	OT_ostta17g02020

BPG:	Bathy06g03350

MIS:	MICPUN_72748

MPP:	MICPUCDRAFT_7426(JGI:MicpuC2_7426)

CME:	CYME_CMN180C

GSL:	Gasu_26060

CCP:	CHC_T00003636001

PGR:	PGTG_09062

PTRC:

PtA15_12A427

PSTR:

Pst134EA_022650 Pst134EA_032114

MLR:	MELLADRAFT_113336

ECU:	ECU08_1860

EIN:	Eint_081810

EHE:	EHEL_081800

ERO:	EROM_081830

NCE:	NCER_100053

MBR:	MONBRDRAFT_14119

SRE:	PTSG_08089

ACAN:

ACA1_053940

TET:	TTHERM_00727660

PTM:	GSPATT00000758001

FCY:	FRACYDRAFT_263994

TPS:	THAPSDRAFT_36249

AAF:	AURANDRAFT_31452

EHX:	EMIHUDRAFT_310659

GTT:	GUITHDRAFT_78344

NGR:	NAEGRDRAFT_73728

TVA:	TVAG_2v0059060

» show all

Reference

PMID:31564433

Authors

Richard EM, Polla DL, Assir MZ, Contreras M, Shahzad M, Khan AA, Razzaq A, Akram J, Tarar MN, Blanpied TA, Ahmed ZM, Abou Jamra R, Wieczorek D, van Bokhoven H, Riazuddin S, Riazuddin S

Title

Bi-allelic Variants in METTL5 Cause Autosomal-Recessive Intellectual Disability and Microcephaly.

Journal

Am J Hum Genet 105:869-878 (2019)
DOI:10.1016/j.ajhg.2019.09.007

Sequence

[hsa:29081]

LinkDB

DBGET integrated database retrieval system