KEGG   ORTHOLOGY: K25011
Entry
K25011                      KO                                     
Symbol
nsp1
Name
SARS coronavirus host translation inhibitor nsp1
Pathway
map03230  Viral genome structure
map03262  Virion - Coronavirus
map05171  Coronavirus disease - COVID-19
Network
nt06171  SARS coronavirus 2 (SARS-CoV-2)
nt06517  TLR signaling
  Element
N01318  SARS-CoV-2 nsp1 to translation initiation
N01321  SARS-CoV-2 nsp1/6/13, ORF3a/6/7b and M to IFN signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K25011  nsp1; SARS coronavirus host translation inhibitor nsp1
   03262 Virion - Coronavirus
    K25011  nsp1; SARS coronavirus host translation inhibitor nsp1
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K25011  nsp1; SARS coronavirus host translation inhibitor nsp1
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K25011  nsp1; SARS coronavirus host translation inhibitor nsp1
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Coronavirus
   K25011  nsp1; SARS coronavirus host translation inhibitor nsp1
Genes
VP: 1489680-1(nsp1) 43740578-1(nsp1)
Reference
PMID:32680882
  Authors
Thoms M, Buschauer R, Ameismeier M, Koepke L, Denk T, Hirschenberger M, Kratzat H, Hayn M, Mackens-Kiani T, Cheng J, Straub JH, Sturzel CM, Frohlich T, Berninghausen O, Becker T, Kirchhoff F, Sparrer KMJ, Beckmann R
  Title
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
  Journal
Science 369:1249-1255 (2020)
DOI:10.1126/science.abc8665
Reference
PMID:32447571
  Authors
Yoshimoto FK
  Title
The Proteins of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2 or n-COV19), the Cause of COVID-19.
  Journal
Protein J 39:198-216 (2020)
DOI:10.1007/s10930-020-09901-4
  Sequence
[vp:43740578-1]
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