KEGG   ORTHOLOGY: K25328
Entry
K25328                      KO                                     
Symbol
NS3
Name
Flavivirus serine protease NS3 catalytic subunit [EC:3.4.21.91 3.6.1.15 5.6.2.6]
Pathway
map03240  Viral replication
map03264  Virion - Flavivirus
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03240 Viral replication
    K25328  NS3; Flavivirus serine protease NS3 catalytic subunit
   03264 Virion - Flavivirus
    K25328  NS3; Flavivirus serine protease NS3 catalytic subunit
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K25328  NS3; Flavivirus serine protease NS3 catalytic subunit
  09185 Viral protein families
   03200 Viral proteins
    K25328  NS3; Flavivirus serine protease NS3 catalytic subunit
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.91  flavivirin
     K25328  NS3; Flavivirus serine protease NS3 catalytic subunit
  3.6  Acting on acid anhydrides
   3.6.1  In phosphorus-containing anhydrides
    3.6.1.15  nucleoside-triphosphate phosphatase
     K25328  NS3; Flavivirus serine protease NS3 catalytic subunit
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.6  RNA 3'-5' helicase
     K25328  NS3; Flavivirus serine protease NS3 catalytic subunit
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S7: flavivirin family
   K25328  NS3; Flavivirus serine protease NS3 catalytic subunit
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Flavivirus
   K25328  NS3; Flavivirus serine protease NS3 catalytic subunit
Other DBs
GO: 0017111 0034458
Genes
VP: 1489713-5(NS3) 1489715-1(NS3) 1489719-5(NS3) 1494449-5(NS3) 1502173-1(NS3) 5075725-5(NS3) 5075727-5(NS3) 5075729-5(NS3) 5075856-1(NS3) 5075863-1(NS3) 5075867-1(NS3) 7751225-5(NS-3) 912267-5(NS3)
Reference
PMID:28461069
  Authors
Shiryaev SA, Farhy C, Pinto A, Huang CT, Simonetti N, Elong Ngono A, Dewing A, Shresta S, Pinkerton AB, Cieplak P, Strongin AY, Terskikh AV
  Title
Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists.
  Journal
Antiviral Res 143:218-229 (2017)
DOI:10.1016/j.antiviral.2017.04.015
  Sequence
[vp:7751225-5]
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