KEGG   MODULE: M00121
Entry
M00121            Pathway   Module                                 
Name
Heme biosynthesis, plants and bacteria, glutamate => heme
Definition
K01885 K02492 K01845 K01698 K01749 (K01719,K13542,K13543) K01599 (K00228,K02495) (K00230,K00231,K08973) K01772
Diagram
M00121

Orthology
K01885  
glutamyl-tRNA synthetase [EC:6.1.1.17] [RN:R05578]
K02492  
glutamyl-tRNA reductase [EC:1.2.1.70] [RN:R04109]
K01845  
glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8] [RN:R02272]
K01698  
porphobilinogen synthase [EC:4.2.1.24] [RN:R00036]
K01749  
hydroxymethylbilane synthase [EC:2.5.1.61] [RN:R00084]
K01719,K13542,K13543  
uroporphyrinogen-III synthase [EC:4.2.1.75] [RN:R03165]
K01599  
uroporphyrinogen decarboxylase [EC:4.1.1.37] [RN:R03197]
K00228  
coproporphyrinogen III oxidase [EC:1.3.3.3] [RN:R03220]
K02495  
oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3] [RN:R06895]
K00230  
menaquinone-dependent protoporphyrinogen oxidase [EC:1.3.5.3] [RN:R09489]
K00231  
protoporphyrinogen oxidase [EC:1.3.3.4] [RN:R03222]
K08973  
protoporphyrinogen IX oxidase [EC:1.3.99.-] [RN:R12605]
K01772  
ferrochelatase [EC:4.99.1.1] [RN:R00310]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00860  Porphyrin metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R05578  
R04109  
R02272  
R00036  
R00084  
R03165  
R03197  
R03220,R06895  
R03222,R09489,R12605  
R00310  
Compound
C00025  L-Glutamate
C02987  L-Glutamyl-tRNA(Glu)
C03741  (S)-4-Amino-5-oxopentanoate
C00430  5-Aminolevulinate
C00931  Porphobilinogen
C01024  Hydroxymethylbilane
C01051  Uroporphyrinogen III
C03263  Coproporphyrinogen III
C01079  Protoporphyrinogen IX
C02191  Protoporphyrin
C00032  Heme
Reference
PMID:28123057
  Authors
Dailey HA, Dailey TA, Gerdes S, Jahn D, Jahn M, O'Brian MR, Warren MJ
  Title
Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product.
  Journal
Microbiol Mol Biol Rev 81:e00048-16 (2017)
DOI:10.1128/MMBR.00048-16
Reference
PMID:32241908
  Authors
Bryant DA, Hunter CN, Warren MJ
  Title
Biosynthesis of the modified tetrapyrroles-the pigments of life.
  Journal
J Biol Chem 295:6888-6925 (2020)
DOI:10.1074/jbc.REV120.006194
LinkDB

DBGET integrated database retrieval system