KEGG   MODULE: M00122
Entry
M00122            Pathway   Module                                 
Name
Cobalamin biosynthesis, cobyrinate a,c-diamide => cobalamin
Definition
(K00798,K19221) K02232 (K02225,K02227) K02231
K00768 (K02226,K22316)
K02233
Diagram
M00122

Orthology
K00798,K19221  
cob(I)alamin adenosyltransferase [EC:2.5.1.17] [RN:R12184]
K02232  
adenosylcobyric acid synthase [EC:6.3.5.10] [RN:R05225]
K02225  
cobalamin biosynthetic protein CobC [RN:R07302 R06529]
K02227  
adenosylcobinamide-phosphate synthase CobD [EC:6.3.1.10] [RN:R07302 R06529]
K02231  
adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62] [RN:R05221 R06558 R05222]
K00768  
nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21] [RN:R04148]
K02226  
alpha-ribazole phosphatase [EC:3.1.3.73] [RN:R04594]
K22316  
adenosylcobalamin/alpha-ribazole phosphatase [EC:3.1.26.4 3.1.3.73] [RN:R04594]
K02233  
adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26] [RN:R05223]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00860  Porphyrin metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
R12184  
R05225  
R07302  
R05221,R06558  
R06529  
R05222  
R04148  
R04594  
R05223  
Compound
C06504  Cob(II)yrinate a,c diamide
C06506  Adenosyl cobyrinate a,c diamide
C06507  Adenosyl cobyrinate hexaamide
C06508  Adenosyl cobinamide
C06509  Adenosyl cobinamide phosphate
C06510  Adenosine-GDP-cobinamide
C03114  Dimethylbenzimidazole
C04778  N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole
C05775  alpha-Ribazole
C00194  Cobamide coenzyme
Reference
PMID:12195810
  Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
  Title
The biosynthesis of adenosylcobalamin (vitamin B12).
  Journal
Nat Prod Rep 19:390-412 (2002)
DOI:10.1039/b108967f
Reference
PMID:32241908
  Authors
Bryant DA, Hunter CN, Warren MJ
  Title
Biosynthesis of the modified tetrapyrroles-the pigments of life.
  Journal
J Biol Chem 295:6888-6925 (2020)
DOI:10.1074/jbc.REV120.006194
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