KEGG   MODULE: M00124
Entry
M00124            Pathway   Module                                 
Name
Pyridoxal-P biosynthesis, erythrose-4P => pyridoxal-P
Definition
K03472 K03473 K00831 K00097 K03474 K00275
Diagram
M00124

Orthology
K03472  
D-erythrose 4-phosphate dehydrogenase [EC:1.2.1.72] [RN:R01825]
K03473  
erythronate-4-phosphate dehydrogenase [EC:1.1.1.290] [RN:R04210]
K00831  
phosphoserine aminotransferase [EC:2.6.1.52] [RN:R05085]
K00097  
4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262] [RN:R05681]
K03474  
pyridoxine 5-phosphate synthase [EC:2.6.99.2] [RN:R05838]
K00275  
pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5] [RN:R00278]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00750  Vitamin B6 metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
Compound
C00279  D-Erythrose 4-phosphate
C03393  4-Phospho-D-erythronate
C06054  2-Oxo-3-hydroxy-4-phosphobutanoate
C06055  O-Phospho-4-hydroxy-L-threonine
C07335  2-Amino-3-oxo-4-phosphonooxybutyrate
C11638  3-Amino-2-oxopropyl phosphate
C00627  Pyridoxine phosphate
C00018  Pyridoxal phosphate
Reference
  Authors
Laber B, Maurer W, Scharf S, Stepusin K, Schmidt FS.
  Title
Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein.
  Journal
FEBS Lett 449:45-8 (1999)
DOI:10.1016/S0014-5793(99)00393-2
Reference
  Authors
Sakai A, Kita M, Tani Y
  Title
Recent progress of vitamin B6 biosynthesis.
  Journal
J Nutr Sci Vitaminol (Tokyo) 50:69-77 (2004)
DOI:10.3177/jnsv.50.69
Reference
  Authors
Fitzpatrick TB, Amrhein N, Kappes B, Macheroux P, Tews I, Raschle T
  Title
Two independent routes of de novo vitamin B6 biosynthesis: not that different after all.
  Journal
Biochem J 407:1-13 (2007)
DOI:10.1042/BJ20070765
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