KEGG   MODULE: M00374
Entry
M00374            Pathway   Module                                 
Name
Dicarboxylate-hydroxybutyrate cycle
Definition
(K00169+K00170+K00171+K00172) K01007 K01595 K00024 (K01677+K01678) (K00239+K00240-K00241-K18860) (K01902+K01903) (K15038,K15017) K14465 (K14467,K18861,K25774) K14534 K15016 K00626
Diagram
M00374

Orthology
K00169,K00170,K00171,K00172  
pyruvate ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196]
K01007  
pyruvate, water dikinase [EC:2.7.9.2] [RN:R00199]
K01595  
phosphoenolpyruvate carboxylase [EC:4.1.1.31] [RN:R00345]
K00024  
malate dehydrogenase [EC:1.1.1.37] [RN:R00342]
K01677,K01678  
fumarate hydratase [EC:4.2.1.2] [RN:R01082]
K00239,K00240,K00241,K18860  
succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164]
K01902,K01903  
succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405]
K15038,K15017  
succinyl-CoA reductase [EC:1.2.1.76] [RN:R09280]
K14465  
succinate semialdehyde reductase (NADPH) [EC:1.1.1.-] [RN:R09281]
K14467,K18861,K25774  
4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40] [RN:R09279]
K14534  
4-hydroxybutyryl-CoA dehydratase [EC:4.2.1.120] [RN:R10782]
K15016  
3-hydroxybutyryl-CoA dehydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35] [RN:R03026 R01975]
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238]
Class
Pathway modules; Energy metabolism; Carbon fixation
Pathway
map00720  Carbon fixation pathways in prokaryotes
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
R01196  
R00199  
R00345  
R00342  
R01082  
R02164  
R00405  
R09280  
R09281  
R09279  
R10782  
R03026  
R01975  
R00238  
Compound
C00024  Acetyl-CoA
C00022  Pyruvate
C00074  Phosphoenolpyruvate
C00036  Oxaloacetate
C00149  (S)-Malate
C00122  Fumarate
C00042  Succinate
C00091  Succinyl-CoA
C00232  Succinate semialdehyde
C00989  4-Hydroxybutanoic acid
C11062  4-Hydroxybutyryl-CoA
C00877  Crotonoyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C00332  Acetoacetyl-CoA
Comment
Organism group: anaerobic hyperthermophilic archaea
Reference
PMID:18511565
  Authors
Huber H, Gallenberger M, Jahn U, Eylert E, Berg IA, Kockelkorn D, Eisenreich W, Fuchs G
  Title
A dicarboxylate/4-hydroxybutyrate autotrophic carbon assimilation cycle in the hyperthermophilic Archaeum Ignicoccus hospitalis.
  Journal
Proc Natl Acad Sci U S A 105:7851-6 (2008)
DOI:10.1073/pnas.0801043105
LinkDB

DBGET integrated database retrieval system