KEGG   MODULE: M00621
Entry
M00621            Pathway   Module                                 
Name
Glycine cleavage system
Definition
(K00281,K00282+K00283) K00605 K00382
Diagram
M00621

Orthology
K00281,K00282+K00283  
glycine dehydrogenase (P protein) [EC:1.4.4.2] [RN:R03425 R01221]
K00605  
aminomethyltransferase (T protein) [EC:2.1.2.10] [RN:R04125 R01221]
K00382  
dihydrolipoyl dehydrogenase (L protein) [EC:1.8.1.4] [RN:R03815 R01221]
Class
Pathway modules; Amino acid metabolism; Serine and threonine metabolism
Pathway
map00260  Glycine, serine and threonine metabolism
map00630  Glyoxylate and dicarboxylate metabolism
map00785  Lipoic acid metabolism
map01200  Carbon metabolism
map01100  Metabolic pathways
Reaction
R03425  
R04125  
R03815  
R01221  
Compound
C00037  Glycine
C02051  [H-protein]-lipoyllysine
C01242  [H-protein]-S-aminomethyldihydrolipoyllysine
C00011  CO2
C00101  Tetrahydrofolate
C02972  [H-protein]-dihydrolipoyllysine
C00143  5,10-Methylenetetrahydrofolate
C00014  Ammonia
Comment
Glycine cleavage system contains the non-enzyme H protein (K02437).
Reference
PMID:10966480
  Authors
Perham RN
  Title
Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions.
  Journal
Annu Rev Biochem 69:961-1004 (2000)
DOI:10.1146/annurev.biochem.69.1.961
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