MODULE: M00661
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Entry
M00661 Pathway Module
Name
Paspaline biosynthesis, geranylgeranyl-PP + indoleglycerol phosphate => paspaline
Definition
K18385 K18386 K18387
Diagram
Orthology
K18385
geranylgeranyldiphosphate transferase [RN:
R10349
]
K18386
FAD dependent monooxygenase [EC:1.14.13.-] [RN:
R10350
R10351
]
K18387
paspaline synthase [RN:
R10352
R10353
]
Ortholog table
Taxonomy
Module table
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other fungal compounds
BRITE hierarchy
Pathway
map00403
Indole diterpene alkaloid biosynthesis
map01100
Metabolic pathways
map01110
Biosynthesis of secondary metabolites
Reaction
R10349
C00353
+
C03506
->
C20525
R10350
C20525
->
C20526
R10352
C20526
->
C20527
R10351
C20527
->
C20529
R10353
C20529
->
C20530
Compound
C00353
Geranylgeranyl diphosphate
C03506
Indoleglycerol phosphate
C20525
3-Geranylgeranylindole
C20526
10,11-Epoxy-3-geranylgeranylindole
C20527
Emindole SB
C20529
14,15-Epoxyemindole SB
C20530
Paspaline
Reference
PMID:
23311903
Authors
Tagami K, Liu C, Minami A, Noike M, Isaka T, Fueki S, Shichijo Y, Toshima H, Gomi K, Dairi T, Oikawa H
Title
Reconstitution of biosynthetic machinery for indole-diterpene paxilline in Aspergillus oryzae.
Journal
J Am Chem Soc 135:1260-3 (2013)
DOI:
10.1021/ja3116636
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