KEGG   MODULE: M00704
Entry
M00704            Signature Module                                 
Name
Tetracycline resistance, efflux pump Tet38
Definition
K18906 K08168
Diagram
M00704

Orthology
K18906  
mgrA; MarR family transcriptional regulator, multiple gene regulator MgrA [COG:COG1846]
K08168  
tetB; MFS transporter, DHA2 family, metal-tetracycline-proton antiporter [COG:COG0477] [TC:2.A.1.3]
Class
Signature modules; Gene set; Drug resistance
Comment
Resistance mechanism: limitation of drug accumulation as a result of active drug efflux
Reference
  Authors
Truong-Bolduc QC, Dunman PM, Strahilevitz J, Projan SJ, Hooper DC
  Title
MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus.
  Journal
J Bacteriol 187:2395-405 (2005)
DOI:10.1128/JB.187.7.2395-2405.2005
Reference
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
LinkDB

DBGET integrated database retrieval system