KEGG   MODULE: M00889
Entry
M00889            Pathway   Module                                 
Name
Puromycin biosynthesis, ATP => puromycin
Definition
K12628 K12629 K12630 K12631 K12632 K12633 K12634 K12635 K12636
Diagram
M00889

Orthology
K12628  
pur10; puromycin biosynthesis protein Pur10 [EC:1.-.-.-] [RN:R05668]
K12629  
pur7; puromycin biosynthesis protein Pur7 [EC:3.-.-.-] [RN:R05669]
K12630  
pur4; puromycin biosynthesis protein Pur4 [EC:2.-.-.-] [RN:R05670]
K12631  
pur6; puromycin biosynthesis protein Pur6 [RN:R05671]
K12632  
pac; puromycin N-acetyltransferase [EC:2.3.-.-] [RN:R05672]
K12633  
pur5; N-methyl-transferase [EC:2.1.1.-] [RN:R05673 R05674]
K12634  
pur3; puromycin biosynthesis protein Pur3 [RN:R05675]
K12635  
dmpM; O-demethylpuromycin O-methyltransferase [EC:2.1.1.38] [RN:R05676]
K12636  
napH; N-acetylpuromycin N-acetylhydrolase [RN:R05677]
Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of other antibiotics
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R05668  
R05669  
R05670  
R05671  
R05672  
R05673  
R05674  
R05675  
R05676  
R05677  
Compound
C00002  ATP
C07024  3'-Keto-3'-deoxy-ATP
C07025  3'-Keto-3'-deoxy-AMP
C07026  3'-Amino-3'-deoxy-AMP
C00082  L-Tyrosine
C07027  N6,N6,O-Tridemethylpuromycin-5'-phosphate
C07028  N-Acetyl-N6,N6,O-tridemethylpuromycin-5'-phosphate
C07029  N-Acetyl-N6,O-didemethylpuromycin-5'-phosphate
C07030  N-Acetyl-O-demethylpuromycin-5'-phosphate
C07031  N-Acetyl-O-demethylpuromycin
C07032  N-Acetylpuromycin
C01610  Puromycin
Reference
PMID:8576156
  Authors
Tercero JA, Espinosa JC, Lacalle RA, Jimenez A.
  Title
The biosynthetic pathway of the aminonucleoside antibiotic puromycin, as deduced from the molecular analysis of the pur cluster of Streptomyces alboniger.
  Journal
J Biol Chem 271:1579-90 (1996)
DOI:10.1074/jbc.271.3.1579
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