KEGG   MODULE: M00924
Entry
M00924            Pathway   Module                                 
Name
Cobalamin biosynthesis, anaerobic, uroporphyrinogen III => sirohydrochlorin => cobyrinate a,c-diamide
Definition
(K02302,(K02303,K13542) (K02304,K24866)) (K02190,K03795,K22011) K03394 (K05934,K13541,K21479) K05936 (K02189,K13541) K02188 K05895 (K02191 K03399,K00595) K06042 K02224
Diagram
M00924

Orthology
K02302  
cysG; uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase [EC:2.1.1.107 1.3.1.76] [RN:R03194 R03947]
K02303,K13542  
cobA; uroporphyrin-III C-methyltransferase [EC:2.1.1.107] [RN:R03194]
K02304,K24866  
MET8, sirC; precorrin-2 dehydrogenase [EC:1.3.1.76] [RN:R03947]
K02190,K03795,K22011  
cbiK, cbiX, cfbA; sirohydrochlorin cobaltochelatase [EC:4.99.1.3] [RN:R05807]
K03394  
cbiL; cobalt-factor-2 C20-methyltransferase [EC:2.1.1.151] [RN:R05808]
K05934,K13541,K21479  
cbiH; cobalt-factor III methyltransferase [EC:2.1.1.272] [RN:R11580]
K05936  
cbiF; cobalt-precorrin-4 C11-methyltransferase [EC:2.1.1.271] [RN:R05810]
K02189,K13541  
cbiG; cobalt-precorrin 5A hydrolase [EC:3.7.1.12] [RN:R07772]
K02188  
cbiD; cobalt-precorrin-5B (C1)-methyltransferase [EC:2.1.1.195] [RN:R07773]
K05895  
cbiJ; cobalt-precorrin-6A reductase [EC:1.3.1.106] [RN:R05812]
K02191  
cbiT; cobalt-precorrin-6B (C15)-methyltransferase [EC:2.1.1.196] [RN:R07774]
K03399  
cbiE; cobalt-precorrin-7 (C5)-methyltransferase [EC:2.1.1.289] [RN:R07775]
K00595  
cbiET; cobalt-precorrin-6B C5,C15-methyltransferase [EC:2.1.1.289 2.1.1.196] [RN:R07775 R07774]
K06042  
cbiC; cobalt-precorrin-8 methylmutase [EC:5.4.99.60] [RN:R05814]
K02224  
cbiA; cobyrinic acid a,c-diamide synthase [EC:6.3.5.11] [RN:R05815]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00860  Porphyrin metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
R03194  
R03947  
R05807  
R05808  
R11580  
R05810  
R07772  
R07773  
R05812  
R07774  
R07775  
R05814  
R05815  
Compound
C01051  Uroporphyrinogen III
C02463  Precorrin 2
C05778  Sirohydrochlorin
C11538  Cobalt-sirohydrochlorin
C17401  Cobalt-factor III
C11540  Cobalt-precorrin 4
C16242  Cobalt-precorrin 5A
C16243  Cobalt-precorrin 5B
C11542  Cobalt-precorrin 6
C11543  Cobalt-dihydro-precorrin 6
C16244  Cobalt-precorrin 7
C11545  Cobalt-precorrin 8
C05773  Cobyrinate
C06504  Cob(II)yrinate a,c diamide
Reference
PMID:22616870
  Authors
Moore SJ, Warren MJ
  Title
The anaerobic biosynthesis of vitamin B12.
  Journal
Biochem Soc Trans 40:581-6 (2012)
DOI:10.1042/BST20120066
Reference
PMID:16042604
  Authors
Frank S, Brindley AA, Deery E, Heathcote P, Lawrence AD, Leech HK, Pickersgill RW, Warren MJ
  Title
Anaerobic synthesis of vitamin B12: characterization of the early steps in the pathway.
  Journal
Biochem Soc Trans 33:811-4 (2005)
DOI:10.1042/BST0330811
Reference
PMID:32241908
  Authors
Bryant DA, Hunter CN, Warren MJ
  Title
Biosynthesis of the modified tetrapyrroles-the pigments of life.
  Journal
J Biol Chem 295:6888-6925 (2020)
DOI:10.1074/jbc.REV120.006194
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