KEGG   MODULE: M00927
Entry
M00927            Pathway   Module                                 
Name
Gibberellin A12 biosynthesis, GAPP => GA12
Definition
K04120 K04121 K04122 K04123
Diagram
M00927

Orthology
K04120  
ent-copalyl diphosphate synthase [EC:5.5.1.13] [RN:R02068]
K04121  
ent-kaurene synthase [EC:4.2.3.19] [RN:R05092]
K04122  
ent-kaurene oxidase [EC:1.14.14.86][RN:R06291 R06292 R06293]
K04123  
ent-kaurenoic acid monooxygenase [EC:1.14.14.107] [RN:R06294 R06295 R06297]
Class
Pathway modules; Biosynthesis of terpenoids and polyketides; Plant terpenoid biosynthesis
Pathway
map00904  Diterpenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C00353  Geranylgeranyl diphosphate
C06089  ent-Copalyl diphosphate
C06090  ent-Kaurene
C11872  Kaur-16-en-18-ol
C11873  Kaur-16-en-18-al
C11874  Kaur-16-en-18-oic acid
C11875  ent-7alpha-Hydroxykaur-16-en-19-oic acid
C06093  Gibberellin A12 aldehyde
C11857  Gibberellin A12
Reference
  Authors
Fleet CM, Yamaguchi S, Hanada A, Kawaide H, David CJ, Kamiya Y, Sun TP
  Title
Overexpression of AtCPS and AtKS in Arabidopsis confers increased ent-kaurene production but no increase in bioactive gibberellins.
  Journal
Plant Physiol 132:830-9 (2003)
DOI:10.1104/pp.103.021725
Reference
  Authors
Magome H, Nomura T, Hanada A, Takeda-Kamiya N, Ohnishi T, Shinma Y, Katsumata T, Kawaide H, Kamiya Y, Yamaguchi S
  Title
CYP714B1 and CYP714B2 encode gibberellin 13-oxidases that reduce gibberellin activity in rice.
  Journal
Proc Natl Acad Sci U S A 110:1947-52 (2013)
DOI:10.1073/pnas.1215788110
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