KEGG   MODULE: M00948
Entry
M00948            Pathway   Module                                 
Name
Hydroxyproline degradation, trans-4-hydroxy-L-proline => 2-oxoglutarate
Definition
K12658 (K21060,K22549+K21061+K22550) K21062 K13877
Diagram
M00948

Orthology
K12658  
4-hydroxyproline epimerase [EC:5.1.1.8] [RN:R03296]
K21060,K22549,K21061,K22550  
D-hydroxyproline dehydrogenase [EC:1.5.99.-] [RN:R11428]
K21062  
1-pyrroline-4-hydroxy-2-carboxylate deaminase [EC:3.5.4.22] [RN:R02280]
K13877  
2,5-dioxopentanoate dehydrogenase [EC:1.2.1.26] [RN:R00264]
Class
Pathway modules; Amino acid metabolism; Other amino acid metabolism
Pathway
map00470  D-Amino acid metabolism
map01100  Metabolic pathways
Reaction
R03296  
R11428  
R02280  
R00264  
Compound
C01157  Hydroxyproline
C03440  cis-4-Hydroxy-D-proline
C04282  1-Pyrroline-4-hydroxy-2-carboxylate
C00433  2,5-Dioxopentanoate
C00026  2-Oxoglutarate
Reference
PMID:22833679
  Authors
Watanabe S, Morimoto D, Fukumori F, Shinomiya H, Nishiwaki H, Kawano-Kawada M, Sasai Y, Tozawa Y, Watanabe Y
  Title
Identification and characterization of D-hydroxyproline dehydrogenase and Delta1-pyrroline-4-hydroxy-2-carboxylate deaminase involved in novel L-hydroxyproline metabolism of bacteria: metabolic convergent evolution.
  Journal
J Biol Chem 287:32674-88 (2012)
DOI:10.1074/jbc.M112.374272
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