KEGG   MODULE: M00950
Entry
M00950            Pathway   Module                                 
Name
Biotin biosynthesis, BioU pathway, pimeloyl-ACP/CoA => biotin
Definition
K00652 K25570 K01935 K01012
Diagram
M00950

Orthology
K00652  
bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47] [RN:R10124 R03210]
K25570  
bioU; 8-amino-7-oxononanoate carboxylating dehydrogenase [EC:2.6.1.121] [RN:R12935]
K01935  
bioD; dethiobiotin synthetase [EC:6.3.3.3] [RN:R12934]
K01012  
bioB; biotin synthase [EC:2.8.1.6] [RN:R01078]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00780  Biotin metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
R10124  
R03210  
R12935  
R12934  
R01078  
Compound
C19845  Pimeloyl-[acyl-carrier protein]
C01092  8-Amino-7-oxononanoate
C01063  Pimeloyl-CoA
C22458  8-Amino-7-(carboxyamino)nonanoate
C01909  Dethiobiotin
C00120  Biotin
Reference
PMID:32042199
  Authors
Sakaki K, Ohishi K, Shimizu T, Kobayashi I, Mori N, Matsuda K, Tomita T, Watanabe H, Tanaka K, Kuzuyama T, Nishiyama M.
  Title
A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria.
  Journal
Nat Chem Biol 16:415-422 (2020)
DOI:10.1038/s41589-019-0461-9
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