| Entry |
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| Name |
Amplified MDM2 to p21-cell cycle G1/S
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| Definition |
MDM2* -| TP53 => CDKN1A -| (CCND+CDK4/6) -> RB1 // E2F |
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| Expanded |
4193v1 -| 7157 => 1026 -| ((595,894,896)+(1019,1021)) -> 5925 // (1869,1870,1871) |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 4193 | MDM2; MDM2 proto-oncogene |
| 7157 | TP53; tumor protein p53 |
| 1026 | CDKN1A; cyclin dependent kinase inhibitor 1A |
| 1019 | CDK4; cyclin dependent kinase 4 |
| 1021 | CDK6; cyclin dependent kinase 6 |
| 5925 | RB1; RB transcriptional corepressor 1 |
| 1869 | E2F1; E2F transcription factor 1 |
| 1870 | E2F2; E2F transcription factor 2 |
| 1871 | E2F3; E2F transcription factor 3 |
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| Variant |
4193v1 (MDM2*) MDM2 amplification
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| Reference |
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| Authors |
Holland EC. |
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| Title |
Gliomagenesis: genetic alterations and mouse models. |
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| Journal |
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| Reference |
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| Authors |
Soni D, King JA, Kaye AH, Hovens CM. |
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| Title |
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge. |
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| Journal |
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| Reference |
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| Authors |
Bansal K, Liang ML, Rutka JT. |
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| Title |
Molecular biology of human gliomas. |
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| Journal |
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| LinkDB |
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