| Entry |
|
|---|
| Name |
Amplified MYC to cell cycle G1/S
|
|---|
| Definition |
(MYC*+MAX) => (CCND+CDK4/6) -> RB1 // E2F |
|---|
| Expanded |
(4609v1+4149) => ((595,894,896)+(1019,1021)) -> 5925 // (1869,1870,1871) |
|---|
| Class |
|
|---|
| Type |
Variant
|
|---|
| Pathway |
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|---|
| Disease |
|
|---|
| Gene |
| 4609 | MYC; MYC proto-oncogene, bHLH transcription factor |
| 4149 | MAX; MYC associated factor X |
| 1019 | CDK4; cyclin dependent kinase 4 |
| 1021 | CDK6; cyclin dependent kinase 6 |
| 5925 | RB1; RB transcriptional corepressor 1 |
| 1869 | E2F1; E2F transcription factor 1 |
| 1870 | E2F2; E2F transcription factor 2 |
| 1871 | E2F3; E2F transcription factor 3 |
|
|---|
| Variant |
4609v1 (MYC*) MYC amplification
|
|---|
| Reference |
|
|---|
| Authors |
Osada H, Takahashi T. |
|---|
| Title |
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. |
|---|
| Journal |
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| LinkDB |
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