NETWORK: N00301
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Entry
N00301 Network
Name
Angiotensin-aldosterone signaling pathway
Definition
AngII -> AGTR1 -> GNAQ -> PLCB -> IP3 -> Ca2+ -> CALM -> CAMK -> CREB => CYP11B2 -> Aldosterone
Expanded
C02135 -> 185 -> 2776 -> (23236,
5330,
5331,
5332) -> C01245 -> C00076 -> (801,
805,
808) -> (8536,
57118,
57172,
815,
816,
817,
818,
814) -> (10488,
1385,
1386,
1388,
148327,
468,
64764,
84699,
90993,
9586) => 1585 -> C01780
Class
nt06316
Renin-angiotensin-aldosterone signaling
Type
Reference
Pathway
hsa04925
Aldosterone synthesis and secretion
Gene
185
AGTR1; angiotensin II receptor type 1
2776
GNAQ; G protein subunit alpha q
23236
PLCB1; phospholipase C beta 1
5330
PLCB2; phospholipase C beta 2
5331
PLCB3; phospholipase C beta 3
5332
PLCB4; phospholipase C beta 4
801
CALM1; calmodulin 1
805
CALM2; calmodulin 2
808
CALM3; calmodulin 3
8536
CAMK1; calcium/calmodulin dependent protein kinase I
57118
CAMK1D; calcium/calmodulin dependent protein kinase ID
57172
CAMK1G; calcium/calmodulin dependent protein kinase IG
815
CAMK2A; calcium/calmodulin dependent protein kinase II alpha
816
CAMK2B; calcium/calmodulin dependent protein kinase II beta
817
CAMK2D; calcium/calmodulin dependent protein kinase II delta
818
CAMK2G; calcium/calmodulin dependent protein kinase II gamma
814
CAMK4; calcium/calmodulin dependent protein kinase IV
10488
CREB3; cAMP responsive element binding protein 3
1385
CREB1; cAMP responsive element binding protein 1
1386
ATF2; activating transcription factor 2
1388
ATF6B; activating transcription factor 6 beta
148327
CREB3L4; cAMP responsive element binding protein 3 like 4
468
ATF4; activating transcription factor 4
64764
CREB3L2; cAMP responsive element binding protein 3 like 2
84699
CREB3L3; cAMP responsive element binding protein 3 like 3
90993
CREB3L1; cAMP responsive element binding protein 3 like 1
9586
CREB5; cAMP responsive element binding protein 5
1585
CYP11B2; cytochrome P450 family 11 subfamily B member 2
Metabolite
C02135
Angiotensin II
C01245
D-myo-Inositol 1,4,5-trisphosphate
C00076
Calcium cation
C01780
Aldosterone
Reference
PMID:
21839803
Authors
Hattangady NG, Olala LO, Bollag WB, Rainey WE
Title
Acute and chronic regulation of aldosterone production.
Journal
Mol Cell Endocrinol 350:151-62 (2012)
DOI:
10.1016/j.mce.2011.07.034
Reference
PMID:
24944029
Authors
Bollag WB
Title
Regulation of aldosterone synthesis and secretion.
Journal
Compr Physiol 4:1017-55 (2014)
DOI:
10.1002/cphy.c130037
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