| | NETWORK: N00324 | |
Entry |
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Name |
CRHR-PKA-ACTH signaling pathway
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Definition |
CRH -> CRHR -> GNAS -> ADCY -> cAMP -> PKA -> CREB -> ACTH |
Expanded |
1392 -> (1394,1395) -> 2778 -> (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568) -> (10488,1385,1386,1388,148327,468,64764,84699,90993,9586) -> 5443 |
Class |
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Type |
Reference
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Pathway |
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Gene |
1392 | CRH; corticotropin releasing hormone |
1394 | CRHR1; corticotropin releasing hormone receptor 1 |
1395 | CRHR2; corticotropin releasing hormone receptor 2 |
2778 | GNAS; GNAS complex locus |
107 | ADCY1; adenylate cyclase 1 |
108 | ADCY2; adenylate cyclase 2 |
109 | ADCY3; adenylate cyclase 3 |
196883 | ADCY4; adenylate cyclase 4 |
111 | ADCY5; adenylate cyclase 5 |
112 | ADCY6; adenylate cyclase 6 |
113 | ADCY7; adenylate cyclase 7 |
114 | ADCY8; adenylate cyclase 8 |
115 | ADCY9; adenylate cyclase 9 |
5566 | PRKACA; protein kinase cAMP-activated catalytic subunit alpha |
5567 | PRKACB; protein kinase cAMP-activated catalytic subunit beta |
5568 | PRKACG; protein kinase cAMP-activated catalytic subunit gamma |
10488 | CREB3; cAMP responsive element binding protein 3 |
1385 | CREB1; cAMP responsive element binding protein 1 |
1386 | ATF2; activating transcription factor 2 |
1388 | ATF6B; activating transcription factor 6 beta |
148327 | CREB3L4; cAMP responsive element binding protein 3 like 4 |
468 | ATF4; activating transcription factor 4 |
64764 | CREB3L2; cAMP responsive element binding protein 3 like 2 |
84699 | CREB3L3; cAMP responsive element binding protein 3 like 3 |
90993 | CREB3L1; cAMP responsive element binding protein 3 like 1 |
9586 | CREB5; cAMP responsive element binding protein 5 |
5443 | POMC; proopiomelanocortin |
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Metabolite |
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Reference |
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Authors |
Kovalovsky D, Refojo D, Liberman AC, Hochbaum D, Pereda MP, Coso OA, Stalla GK, Holsboer F, Arzt E |
Title |
Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways. |
Journal |
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Reference |
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Authors |
Subbannayya T, Balakrishnan L, Sudarshan G, Advani J, Kumar S, Mahmood R, Nair B, Sirdeshmukh R, Mukherjee KK, Umathe SN, Raju R, Prasad TS |
Title |
An integrated map of corticotropin-releasing hormone signaling pathway. |
Journal |
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LinkDB |
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