| Entry |
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| Name |
cGAS-STING signaling pathway
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| Definition |
DNA -> CGAS -> cGAMP -> STING1 -> TBK1 -> IRF3 => (IFNA,IFNB) |
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| Expanded |
C00039 -> 115004 -> C20640 -> 340061 -> 29110 -> 3661 => (3439,3440,3441,3442,3443,3444,3445,3446,3447,3448,3449,3451,3452,3456) |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 115004 | CGAS; cyclic GMP-AMP synthase |
| 340061 | STING1; stimulator of interferon response cGAMP interactor 1 |
| 29110 | TBK1; TANK binding kinase 1 |
| 3661 | IRF3; interferon regulatory factor 3 |
| 3439 | IFNA1; interferon alpha 1 |
| 3440 | IFNA2; interferon alpha 2 |
| 3441 | IFNA4; interferon alpha 4 |
| 3442 | IFNA5; interferon alpha 5 |
| 3443 | IFNA6; interferon alpha 6 |
| 3444 | IFNA7; interferon alpha 7 |
| 3445 | IFNA8; interferon alpha 8 |
| 3446 | IFNA10; interferon alpha 10 |
| 3447 | IFNA13; interferon alpha 13 |
| 3448 | IFNA14; interferon alpha 14 |
| 3449 | IFNA16; interferon alpha 16 |
| 3451 | IFNA17; interferon alpha 17 |
| 3452 | IFNA21; interferon alpha 21 |
| 3456 | IFNB1; interferon beta 1 |
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| Metabolite |
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| Reference |
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| Authors |
Ma Z, Damania B |
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| Title |
The cGAS-STING Defense Pathway and Its Counteraction by Viruses. |
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| Journal |
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| Reference |
|
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| Authors |
Lam E, Stein S, Falck-Pedersen E |
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| Title |
Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade. |
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| Journal |
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| Reference |
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| Authors |
Liu S, Cai X, Wu J, Cong Q, Chen X, Li T, Du F, Ren J, Wu YT, Grishin NV, Chen ZJ |
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| Title |
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. |
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| Journal |
|
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| Reference |
|
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| Authors |
Chen Q, Sun L, Chen ZJ |
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| Title |
Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing. |
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| Journal |
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| LinkDB |
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