Homo sapiens (human): 3440
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Entry
3440 CDS
T01001
Symbol
IFNA2, IFN-alpha-2, IFN-alphaA, IFNA, IFNA2B, leIF_A
Name
(RefSeq) interferon alpha 2
KO
K05414
interferon alpha
Organism
hsa
Homo sapiens (human)
Pathway
hsa04060
Cytokine-cytokine receptor interaction
hsa04151
PI3K-Akt signaling pathway
hsa04217
Necroptosis
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04622
RIG-I-like receptor signaling pathway
hsa04623
Cytosolic DNA-sensing pathway
hsa04630
JAK-STAT signaling pathway
hsa04650
Natural killer cell mediated cytotoxicity
hsa04936
Alcoholic liver disease
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05161
Hepatitis B
hsa05162
Measles
hsa05163
Human cytomegalovirus infection
hsa05164
Influenza A
hsa05165
Human papillomavirus infection
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05200
Pathways in cancer
hsa05320
Autoimmune thyroid disease
hsa05417
Lipid and atherosclerosis
Network
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06163
Hepatitis C virus (HCV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06166
Human papillomavirus (HPV)
nt06167
Human cytomegalovirus (HCMV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06170
Influenza A virus (IAV)
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06182
Shigella
nt06222
IFN signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06517
TLR signaling
nt06518
JAK-STAT signaling
nt06519
RLR signaling
nt06520
CGAS-STING signaling
nt06527
Necroptosis
Element
N00148
TLR3-IRF7 signaling pathway
N00150
Type I IFN signaling pathway
N00395
cGAS-STING signaling pathway
N00436
HIV Tat to TLR2/4-NFKB signaling pathway
N00469
RIG-I-IRF7/3 signaling pathway
N00688
RIG-I-NFKB signaling pathway
N00690
TLR7/9-IRF7 signaling pathway
N01308
MDA5-IRF7/3 signaling pathway
N01543
TLR7/8/9-IRF5 signaling pathway
N01558
Type I interferon to Jak-STAT signaling pathway
N01559
Type II interferon to Jak-STAT signaling pathway
N01662
IFN-RIPK1/3 signaling pathway
Drug target
Nadofaragene firadenovec:
D12531
<US>
Rontalizumab:
D09662
Sifalimumab:
D09668
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
3440 (IFNA2)
04151 PI3K-Akt signaling pathway
3440 (IFNA2)
09133 Signaling molecules and interaction
04060 Cytokine-cytokine receptor interaction
3440 (IFNA2)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
3440 (IFNA2)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
3440 (IFNA2)
04621 NOD-like receptor signaling pathway
3440 (IFNA2)
04622 RIG-I-like receptor signaling pathway
3440 (IFNA2)
04623 Cytosolic DNA-sensing pathway
3440 (IFNA2)
04650 Natural killer cell mediated cytotoxicity
3440 (IFNA2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3440 (IFNA2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
3440 (IFNA2)
05161 Hepatitis B
3440 (IFNA2)
05160 Hepatitis C
3440 (IFNA2)
05171 Coronavirus disease - COVID-19
3440 (IFNA2)
05164 Influenza A
3440 (IFNA2)
05162 Measles
3440 (IFNA2)
05168 Herpes simplex virus 1 infection
3440 (IFNA2)
05163 Human cytomegalovirus infection
3440 (IFNA2)
05167 Kaposi sarcoma-associated herpesvirus infection
3440 (IFNA2)
05169 Epstein-Barr virus infection
3440 (IFNA2)
05165 Human papillomavirus infection
3440 (IFNA2)
09171 Infectious disease: bacterial
05152 Tuberculosis
3440 (IFNA2)
09163 Immune disease
05320 Autoimmune thyroid disease
3440 (IFNA2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
3440 (IFNA2)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
3440 (IFNA2)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04052 Cytokines and neuropeptides [BR:
hsa04052
]
3440 (IFNA2)
Cytokines and neuropeptides [BR:
hsa04052
]
Cytokines
Interferons
3440 (IFNA2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Interferon
iSTAND
Motif
Other DBs
NCBI-GeneID:
3440
NCBI-ProteinID:
NP_000596
OMIM:
147562
HGNC:
5423
Ensembl:
ENSG00000188379
UniProt:
P01563
A0A7R8GUN5
Structure
PDB
LinkDB
All DBs
Position
9:complement(21384255..21385398)
Genome browser
AA seq
188 aa
AA seq
DB search
MALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFG
FPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEA
CVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNL
QESLRSKE
NT seq
567 nt
NT seq
+upstream
nt +downstream
nt
atggccttgacctttgctttactggtggccctcctggtgctcagctgcaagtcaagctgc
tctgtgggctgtgatctgcctcaaacccacagcctgggtagcaggaggaccttgatgctc
ctggcacagatgaggagaatctctcttttctcctgcttgaaggacagacatgactttgga
tttccccaggaggagtttggcaaccagttccaaaaggctgaaaccatccctgtcctccat
gagatgatccagcagatcttcaatctcttcagcacaaaggactcatctgctgcttgggat
gagaccctcctagacaaattctacactgaactctaccagcagctgaatgacctggaagcc
tgtgtgatacagggggtgggggtgacagagactcccctgatgaaggaggactccattctg
gctgtgaggaaatacttccaaagaatcactctctatctgaaagagaagaaatacagccct
tgtgcctgggaggttgtcagagcagaaatcatgagatctttttctttgtcaacaaacttg
caagaaagtttaagaagtaaggaatga
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integrated database retrieval system