| Entry |
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| Name |
HCMV vIL10 to IL10-JAK-STAT signaling pathway
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| Definition |
vIL10 -> IL10R -> JAK1 -> STAT3 |
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| Expanded |
K21533 -> (3587+3588) -> 3716 -> 6774 |
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| Class |
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| Type |
Pathogen
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| Pathway |
| hsa05163 | Human cytomegalovirus infection |
| hsa04061 | Viral protein interaction with cytokine and cytokine receptor |
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| Disease |
| H00368 | Cytomegalovirus infection |
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| Gene |
| 3587 | IL10RA; interleukin 10 receptor subunit alpha |
| 3588 | IL10RB; interleukin 10 receptor subunit beta |
| 3716 | JAK1; Janus kinase 1 |
| 6774 | STAT3; signal transducer and activator of transcription 3 |
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| Perturbant |
| K21533 (vIL10) | vIL10; EBV viral interleukin 10 |
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| Reference |
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| Authors |
Tu CC, Arnolds KL, O'Connor CM, Spencer JV |
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| Title |
Human Cytomegalovirus UL111A and US27 Gene Products Enhance the CXCL12/CXCR4 Signaling Axis via Distinct Mechanisms. |
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| Journal |
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| Reference |
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| Authors |
Jenkins C, Garcia W, Godwin MJ, Spencer JV, Stern JL, Abendroth A, Slobedman B |
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| Title |
Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection. |
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| Journal |
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| Reference |
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| Authors |
Spencer JV, Lockridge KM, Barry PA, Lin G, Tsang M, Penfold ME, Schall TJ |
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| Title |
Potent immunosuppressive activities of cytomegalovirus-encoded interleukin-10. |
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| Journal |
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| Reference |
|
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| Authors |
Magel GD (ed). |
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| Title |
Herpesviridae -A look into this unique family of viruses- |
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| Journal |
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| LinkDB |
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