KEGG   NETWORK: N00444
Entry
N00444                      Network                                
Name
TNF-p38 signaling pathway
Definition
TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> (TAK1+TAB1/2) -> MKK3/6 -> MAPK14 -> MSK1/2 -> CREB
  Expanded
7124 -> 7132 -> (8737+8717+(7186,7188)) -> (6885+(10454,23118)) -> (5606,5608) -> 1432 -> (8986,9252) -> (10488,1385,1386,1388,148327,468,64764,84699,90993,9586)
Class
nt06516 TNF signaling
nt06161 Human immunodeficiency virus 1 (HIV-1)
nt06180 Pathogenic Escherichia coli
Type
Reference
Pathway
hsa04668  TNF signaling pathway
Gene
7124  TNF; tumor necrosis factor
7132  TNFRSF1A; TNF receptor superfamily member 1A
8737  RIPK1; receptor interacting serine/threonine kinase 1
8717  TRADD; TNFRSF1A associated via death domain
7186  TRAF2; TNF receptor associated factor 2
7188  TRAF5; TNF receptor associated factor 5
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7
10454  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1
23118  TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
5606  MAP2K3; mitogen-activated protein kinase kinase 3
5608  MAP2K6; mitogen-activated protein kinase kinase 6
1432  MAPK14; mitogen-activated protein kinase 14
8986  RPS6KA4; ribosomal protein S6 kinase A4
9252  RPS6KA5; ribosomal protein S6 kinase A5
10488  CREB3; cAMP responsive element binding protein 3
1385  CREB1; cAMP responsive element binding protein 1
1386  ATF2; activating transcription factor 2
1388  ATF6B; activating transcription factor 6 beta
148327  CREB3L4; cAMP responsive element binding protein 3 like 4
468  ATF4; activating transcription factor 4
64764  CREB3L2; cAMP responsive element binding protein 3 like 2
84699  CREB3L3; cAMP responsive element binding protein 3 like 3
90993  CREB3L1; cAMP responsive element binding protein 3 like 1
9586  CREB5; cAMP responsive element binding protein 5
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
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