NETWORK: N00948
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Entry
N00948 Network
Name
Shigella IpaH7.8 to NLRP3 Inflammasome signaling pathway
Definition
IpaH7.8 -| GLMN -| (NLRP3+PYCARD) -> CASP1 -> IL1B
Expanded
K23834 -| 11146 -| (114548+29108) -> 834 -> 3553
Class
nt06521
NLR signaling
nt06182
Shigella
Type
Pathogen
Pathway
hsa05131
Shigellosis
Disease
H00299
Shigellosis
Gene
11146
GLMN; glomulin, FKBP associated protein
114548
NLRP3; NLR family pyrin domain containing 3
29108
PYCARD; PYD and CARD domain containing
834
CASP1; caspase 1
3553
IL1B; interleukin 1 beta
Perturbant
K23834
(IpaH7.8)
ipaH7.8; E3 ubiquitin-protein ligase IpaH7.8
Reference
PMID:
25246571
Authors
Suzuki S, Mimuro H, Kim M, Ogawa M, Ashida H, Toyotome T, Franchi L, Suzuki M, Sanada T, Suzuki T, Tsutsui H, Nunez G, Sasakawa C
Title
Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages.
Journal
Proc Natl Acad Sci U S A 111:E4254-63 (2014)
DOI:
10.1073/pnas.1324021111
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