Entry |
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Name |
SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
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Definition |
S -| ACE2 -| AngII -> AGTR1 -> NOX2 -> ROS -> NFKB -> (TNF,IL6,IL1B,IL12,MMP3,MMP1,CCL2,CXCL8) |
Expanded |
K24152 -| 59272 -| C02135 -> 185 -> 1536 -> (C00704+C00027) -> (4790+5970) -> (7124,3569,3553,3592,3593,4314,4312,6347,3576) |
Class |
nt06171 SARS coronavirus 2 (SARS-CoV-2)
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Type |
Pathogen
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Pathway |
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Disease |
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Gene |
59272 | ACE2; angiotensin I converting enzyme 2 |
185 | AGTR1; angiotensin II receptor type 1 |
1536 | CYBB; cytochrome b-245 beta chain |
4790 | NFKB1; nuclear factor kappa B subunit 1 |
5970 | RELA; RELA proto-oncogene, NF-kB subunit |
7124 | TNF; tumor necrosis factor |
3553 | IL1B; interleukin 1 beta |
3592 | IL12A; interleukin 12A |
3593 | IL12B; interleukin 12B |
4314 | MMP3; matrix metallopeptidase 3 |
4312 | MMP1; matrix metallopeptidase 1 |
6347 | CCL2; C-C motif chemokine ligand 2 |
3576 | CXCL8; C-X-C motif chemokine ligand 8 |
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Perturbant |
K24152 (S) | S; SARS coronavirus spike glycoprotein |
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Metabolite |
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Reference |
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Authors |
Gubernatorova EO, Gorshkova EA, Polinova AI, Drutskaya MS |
Title |
IL-6: Relevance for immunopathology of SARS-CoV-2. |
Journal |
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Reference |
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Authors |
Banu N, Panikar SS, Leal LR, Leal AR |
Title |
Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications. |
Journal |
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Reference |
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Authors |
Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS |
Title |
Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. |
Journal |
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Reference |
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Authors |
Magro C, Mulvey JJ, Berlin D, Nuovo G, Salvatore S, Harp J, Baxter-Stoltzfus A, Laurence J |
Title |
Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases. |
Journal |
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LinkDB |
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