Homo sapiens (human): 1536
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Entry
1536 CDS
T01001
Symbol
CYBB, AMCBX2, CGD, CGDX, GP91-1, GP91-PHOX, GP91PHOX, IMD34, NOX2, p91-PHOX
Name
(RefSeq) cytochrome b-245 beta chain
KO
K21421
NADPH oxidase 2 [EC:1.-.-.-]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04066
HIF-1 signaling pathway
hsa04145
Phagosome
hsa04216
Ferroptosis
hsa04217
Necroptosis
hsa04613
Neutrophil extracellular trap formation
hsa04621
NOD-like receptor signaling pathway
hsa04670
Leukocyte transendothelial migration
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa05010
Alzheimer disease
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05140
Leishmaniasis
hsa05171
Coronavirus disease - COVID-19
hsa05415
Diabetic cardiomyopathy
hsa05417
Lipid and atherosclerosis
Network
nt06171
SARS coronavirus 2 (SARS-CoV-2)
nt06465
Prion disease
Element
N01204
PRNP-PI3K-NOX2 signaling pathway
N01205
Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway
N01306
AngII-AT1R-NOX2 signaling pathway
N01307
SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway
Disease
H00089
IFN-gamma/IL-12 axis
H00098
Chronic granulomatous disease
H01167
Granulibacter infection
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04066 HIF-1 signaling pathway
1536 (CYBB)
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
1536 (CYBB)
09143 Cell growth and death
04216 Ferroptosis
1536 (CYBB)
04217 Necroptosis
1536 (CYBB)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
1536 (CYBB)
04621 NOD-like receptor signaling pathway
1536 (CYBB)
04670 Leukocyte transendothelial migration
1536 (CYBB)
09160 Human Diseases
09172 Infectious disease: viral
05171 Coronavirus disease - COVID-19
1536 (CYBB)
09174 Infectious disease: parasitic
05140 Leishmaniasis
1536 (CYBB)
09164 Neurodegenerative disease
05010 Alzheimer disease
1536 (CYBB)
05020 Prion disease
1536 (CYBB)
05022 Pathways of neurodegeneration - multiple diseases
1536 (CYBB)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
1536 (CYBB)
05415 Diabetic cardiomyopathy
1536 (CYBB)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
1536 (CYBB)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
1536 (CYBB)
Membrane trafficking [BR:
hsa04131
]
Others
NADPH oxidases (Nox) and associated proteins
NADPH oxidases
1536 (CYBB)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
NAD_binding_6
FAD_binding_8
Ferric_reduct
FAD_binding_6
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
1536
NCBI-ProteinID:
NP_000388
OMIM:
300481
HGNC:
2578
Ensembl:
ENSG00000165168
UniProt:
P04839
A0A0S2Z3S6
Structure
PDB
LinkDB
All DBs
Position
X:37780059..37813461
Genome browser
AA seq
570 aa
AA seq
DB search
MGNWAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACL
NFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNLTFHKMVAWMIALHSAIHTIAHL
FNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGV
VITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHN
ITVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKV
VTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGD
WTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASIL
KSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYL
TGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPE
ALAETLSKQSISNSESGPRGVHFIFNKENF
NT seq
1713 nt
NT seq
+upstream
nt +downstream
nt
atggggaactgggctgtgaatgaggggctctccatttttgtcattctggtttggctgggg
ttgaacgtcttcctctttgtctggtattaccgggtttatgatattccacctaagttcttt
tacacaagaaaacttcttgggtcagcactggcactggccagggcccctgcagcctgcctg
aatttcaactgcatgctgattctcttgccagtctgtcgaaatctgctgtccttcctcagg
ggttccagtgcgtgctgctcaacaagagttcgaagacaactggacaggaatctcaccttt
cataaaatggtggcatggatgattgcacttcactctgcgattcacaccattgcacatcta
tttaatgtggaatggtgtgtgaatgcccgagtcaataattctgatccttattcagtagca
ctctctgaacttggagacaggcaaaatgaaagttatctcaattttgctcgaaagagaata
aagaaccctgaaggaggcctgtacctggctgtgaccctgttggcaggcatcactggagtt
gtcatcacgctgtgcctcatattaattatcacttcctccaccaaaaccatccggaggtct
tactttgaagtcttttggtacacacatcatctctttgtgatcttcttcattggccttgcc
atccatggagctgaacgaattgtacgtgggcagaccgcagagagtttggctgtgcataat
ataacagtttgtgaacaaaaaatctcagaatggggaaaaataaaggaatgcccaatccct
cagtttgctggaaaccctcctatgacttggaaatggatagtgggtcccatgtttctgtat
ctctgtgagaggttggtgcggttttggcgatctcaacagaaggtggtcatcaccaaggtg
gtcactcaccctttcaaaaccatcgagctacagatgaagaagaaggggttcaaaatggaa
gtgggacaatacatttttgtcaagtgcccaaaggtgtccaagctggagtggcaccctttt
acactgacatccgcccctgaggaagacttctttagtatccatatccgcatcgttggggac
tggacagaggggctgttcaatgcttgtggctgtgataagcaggagtttcaagatgcgtgg
aaactacctaagatagcggttgatgggccctttggcactgccagtgaagatgtgttcagc
tatgaggtggtgatgttagtgggagcagggattggggtcacacccttcgcatccattctc
aagtcagtctggtacaaatattgcaataacgccaccaatctgaagctcaaaaagatctac
ttctactggctgtgccgggacacacatgcctttgagtggtttgcagatctgctgcaactg
ctggagagccagatgcaggaaaggaacaatgccggcttcctcagctacaacatctacctc
actggctgggatgagtctcaggccaatcactttgctgtgcaccatgatgaggagaaagat
gtgatcacaggcctgaaacaaaagactttgtatggacggcccaactgggataatgaattc
aagacaattgcaagtcaacaccctaataccagaataggagttttcctctgtggacctgaa
gccttggctgaaaccctgagtaaacaaagcatctccaactctgagtctggccctcgggga
gtgcatttcattttcaacaaggaaaacttctaa
DBGET
integrated database retrieval system