KEGG   NETWORK: N01343
Entry
N01343                      Network                                
Name
ACH-CHRN-RAS-ERK signaling pathway
Definition
ACh -> CHRNA7 -> Ca2+ -> RAS -> RAF -> MEK -> ERK -> CREB
  Expanded
C01996 -> 1139 -> C00076 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> (10488,1385,1386,1388,148327,468,64764,84699,90993,9586)
Class
nt06210 ERK signaling (cancer)
Type
Reference
Gene
1139  CHRNA7; cholinergic receptor nicotinic alpha 7 subunit
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
10488  CREB3; cAMP responsive element binding protein 3
1385  CREB1; cAMP responsive element binding protein 1
1386  ATF2; activating transcription factor 2
1388  ATF6B; activating transcription factor 6 beta
148327  CREB3L4; cAMP responsive element binding protein 3 like 4
468  ATF4; activating transcription factor 4
64764  CREB3L2; cAMP responsive element binding protein 3 like 2
84699  CREB3L3; cAMP responsive element binding protein 3 like 3
90993  CREB3L1; cAMP responsive element binding protein 3 like 1
9586  CREB5; cAMP responsive element binding protein 5
Metabolite
C01996  Acetylcholine
C00076  Calcium cation
Reference
  Authors
Akaike A, Izumi Y
  Title
Overview
  Journal
Nicotinic Acetylcholine Receptor Signaling in Neuroprotection(2018)
DOI:10.1007/978-981-10-8488-1
Reference
  Authors
Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
  Journal
Clin Cancer Res 17:3533-41 (2011)
DOI:10.1158/1078-0432.CCR-10-2434
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