KEGG   NETWORK: N01690
Entry
N01690                      Network                                
Name
Blood group H antigen type 4 (Globo-H) biosynthesis
Definition
P -- B3GALT5 -> Gb5Cer -- FUT1/2*H -> TypeIVH(Globo-H) // ABO*O/A2
  Expanded
G00094 -- 10317 -> G00097 -- (2523v1,2524v1) -> G00099 // (28v3,28v4)
Class
nt06035 Blood group carbohydrate antigen biosynthesis
Type
Reference
Pathway
hsa00603  Glycosphingolipid biosynthesis - globo and isoglobo series
Gene
10317  B3GALT5; beta-1,3-galactosyltransferase 5
2523  FUT1; fucosyltransferase 1 (H blood group)
2524  FUT2; fucosyltransferase 2
28  ABO; ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
Variant
2523v1 (FUT1*H)  FUT1 H allele
2524v1 (FUT2*H)  FUT2 Se allele
28v3 (ABO*O)  ABO O allele
28v4 (ABO*A2)  ABO A2 allele
Metabolite
G00094  Globoside
G00097  Galactosylgloboside
G00099  Globo-H
Reference
PMID:3944092
  Authors
Clausen H, Holmes E, Hakomori S
  Title
Novel blood group H glycolipid antigens exclusively expressed in blood group A and AB erythrocytes (type 3 chain H). II. Differential conversion of different H  substrates by A1 and A2 enzymes, and type 3 chain H expression in relation to  secretor status.
  Journal
J Biol Chem 261:1388-92 (1986)
Reference
PMID:18685093 (Erratum in: Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17206)
  Authors
Chang WW, Lee CH, Lee P, Lin J, Hsu CW, Hung JT, Lin JJ, Yu JC, Shao LE, Yu J, Wong CH, Yu AL
  Title
Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis.
  Journal
Proc Natl Acad Sci U S A 105:11667-72 (2008)
DOI:10.1073/pnas.0804979105
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