KEGG   NETWORK: N01747
Entry
N01747                      Network                                
Name
Find-me signal (nucleotide)
Definition
CASP3,CASP7 -> PANX1 -- (ATP,UTP,ADP,UDP) -> P2Y
  Expanded
836,840 -> 24145 -- (C00002,C00075,C00008,C00015) -> (5029,5031,64805)
Class
nt06535 Efferocytosis
Type
Reference
Pathway
hsa04148  Efferocytosis
Gene
836  CASP3; caspase 3
840  CASP7; caspase 7
24145  PANX1; pannexin 1
5029  P2RY2; purinergic receptor P2Y2
5031  P2RY6; pyrimidinergic receptor P2Y6
64805  P2RY12; purinergic receptor P2Y12
Metabolite
C00002  ATP
C00075  UTP
C00008  ADP
C00015  UDP
Reference
  Authors
Li Y, Li Q, Fan GC
  Title
Macrophage Efferocytosis in Cardiac Pathophysiology and Repair.
  Journal
Shock 55:177-188 (2021)
DOI:10.1097/SHK.0000000000001625
Reference
  Authors
Butler CA, Popescu AS, Kitchener EJA, Allendorf DH, Puigdellivol M, Brown GC
  Title
Microglial phagocytosis of neurons in neurodegeneration, and its regulation.
  Journal
J Neurochem 158:621-639 (2021)
DOI:10.1111/jnc.15327
Reference
  Authors
Chekeni FB, Elliott MR, Sandilos JK, Walk SF, Kinchen JM, Lazarowski ER, Armstrong AJ, Penuela S, Laird DW, Salvesen GS, Isakson BE, Bayliss DA, Ravichandran KS
  Title
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis.
  Journal
Nature 467:863-7 (2010)
DOI:10.1038/nature09413
Reference
  Authors
Ravichandran KS
  Title
Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways.
  Journal
Immunity 35:445-55 (2011)
DOI:10.1016/j.immuni.2011.09.004
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