KEGG   REACTION: R00740
Entry
R00740                      Reaction                               
Name
3-oxopropanoate:NADP+ oxidoreductase (CoA-malonylating)
Definition
3-Oxopropanoate + CoA + NADP+ <=> Malonyl-CoA + NADPH + H+
Equation
C00222 + C00010 + C00006 <=> C00083 + C00005 + C00080
Reaction class
RC00001  C00005_C00006
RC00004  C00010_C00083
RC00184  C00083_C00222
Enzyme
1.2.1.75
Pathway
rn00640  Propanoate metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00375  Hydroxypropionate-hydroxybutylate cycle
M00376  3-Hydroxypropionate bi-cycle
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.75
     R00740  3-Oxopropanoate + CoA + NADP+ <=> Malonyl-CoA + NADPH + H+
Overall reaction [br08210.html]
 Carbon fixation
  R00740
Orthology
K14468  malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+) [EC:1.2.1.75 1.1.1.298]
K15017  malonyl-CoA/succinyl-CoA reductase (NADPH) [EC:1.2.1.75 1.2.1.76]
Other DBs
RHEA: 26449
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