KEGG   REACTION: R00742
Entry
R00742                      Reaction                               
Name
acetyl-CoA:carbon-dioxide ligase (ADP-forming)
Definition
ATP + Acetyl-CoA + HCO3- <=> ADP + Orthophosphate + Malonyl-CoA
Equation
C00002 + C00024 + C00288 <=> C00008 + C00009 + C00083
Comment
two-step reaction (see R04385 + R04386)
Reaction class
RC00002  C00002_C00008
RC00040  C00024_C00083
RC00367  C00083_C00288
Enzyme
6.4.1.2
Pathway
rn00061  Fatty acid biosynthesis
rn00254  Aflatoxin biosynthesis
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01212  Fatty acid metabolism
Module
M00082  Fatty acid biosynthesis, initiation
M00375  Hydroxypropionate-hydroxybutylate cycle
M00376  3-Hydroxypropionate bi-cycle
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.4  Forming carbon-carbon bonds
   6.4.1  Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
    6.4.1.2
     R00742  ATP + Acetyl-CoA + HCO3- <=> ADP + Orthophosphate + Malonyl-CoA
Overall reaction [br08210.html]
 Carbon fixation
  R00742
Orthology
K01946  acetyl-CoA carboxylase / biotin carboxylase 2 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K01961  acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
K01962  acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
K01963  acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
K01964  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3]
K02160  acetyl-CoA carboxylase biotin carboxyl carrier protein
K11262  acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K11263  acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.3.4.14]
K15036  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K15037  biotin carboxyl carrier protein
K18472  acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K18603  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3]
K18604  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K18605  biotin carboxyl carrier protein
K19312  acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K22568  acetyl-CoA/propionyl-CoA carboxylase, PccX subunit [EC:6.4.1.2 6.4.1.3]
Other DBs
RHEA: 11311
LinkDB

KEGG   REACTION: R04385
Entry
R04385                      Reaction                               
Name
biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming)
Definition
ATP + Holo-[carboxylase] + HCO3- <=> ADP + Orthophosphate + Carboxybiotin-carboxyl-carrier protein
Equation
C00002 + C06250 + C00288 <=> C00008 + C00009 + C04419
Comment
The first step of two-step reaction (R00742)
subsequently R04386
Reaction class
RC00002  C00002_C00008
RC00253  C04419_C06250
Enzyme
6.3.4.14
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.14
     R04385  ATP + Holo-[carboxylase] + HCO3- <=> ADP + Orthophosphate + Carboxybiotin-carboxyl-carrier protein
Orthology
K01961  acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
K11262  acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K11263  acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.3.4.14]
Other DBs
RHEA: 13504
LinkDB

KEGG   REACTION: R04386
Entry
R04386                      Reaction                               
Name
carboxybiotin-carboxyl-carrier-protein:acetyl-CoA carboxytransferase
Definition
Acetyl-CoA + Carboxybiotin-carboxyl-carrier protein <=> Malonyl-CoA + Holo-[carboxylase]
Equation
C00024 + C04419 <=> C00083 + C06250
Comment
The second step of two-step reaction (R00742)
following after R04385
Reaction class
RC00040  C00024_C00083
RC00253  C04419_C06250
Enzyme
2.1.3.15
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.15
     R04386  Acetyl-CoA + Carboxybiotin-carboxyl-carrier protein <=> Malonyl-CoA + Holo-[carboxylase]
Orthology
K01962  acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
K01963  acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
K11262  acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K15036  acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15]
K18472  acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15]
Other DBs
RHEA: 54731
LinkDB

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