KEGG   REACTION: R01169
Entry
R01169                      Reaction                               
Name
S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase
Definition
L-Histidine + 3 S-Adenosyl-L-methionine + H+ <=> Hercynine + 3 S-Adenosyl-L-homocysteine
Equation
Comment
three-step reaction (see R10523+R10524+R04436)
Reaction class
RC00003  C00019_C00021
RC02308  C00135_C05575
Enzyme
Pathway
rn00340  Histidine metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.44
     R01169  L-Histidine + 3 S-Adenosyl-L-methionine + H+ <=> Hercynine + 3 S-Adenosyl-L-homocysteine
Orthology
K18911  L-histidine Nalpha-methyltransferase [EC:2.1.1.44]
K20246  L-histidine Nalpha-methyltransferase / hercynylcysteine S-oxide synthase [EC:2.1.1.44 1.21.3.10]
Reference
1  [PMID:5484456]
  Authors
Ishikawa Y, Melville DB.
  Title
The enzymatic alpha-N-methylation of histidine.
  Journal
J Biol Chem 245:5967-73 (1970)
DOI:10.1016/S0021-9258(18)62649-3
Other DBs
RHEA: 38474
LinkDB

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