KEGG   REACTION: R01699
Entry
R01699                      Reaction                               
Name
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Definition
Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
Equation
C00022 + C15972 <=> C16255 + C00011
Comment
pyruvate dehydrogenase complex: pyruvate dehydrogenase
a part of multi-step reaction (see R00209, R01699+R02569+R07618)
subsequently R02569
TPP-dependent enzyme (see R00014+R03270)
Reaction class
RC00627  C15972_C16255
Enzyme
1.2.4.1
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1
     R01699  Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
Orthology
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
Other DBs
RHEA: 19192
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