KEGG   REACTION: R02219
Entry
R02219                      Reaction                               
Name
3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase;
3-oxo-5beta-steroid: (acceptor) delta4-oxidoreductase
Definition
Progesterone + NADPH + H+ <=> 5beta-Pregnane-3,20-dione + NADP+
Equation
C00410 + C00005 + C00080 <=> C05479 + C00006
Reaction class
RC00001  C00005_C00006
RC00145  C00410_C05479
Enzyme
1.3.1.3         1.3.99.6
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.3
     R02219  Progesterone + NADPH + H+ <=> 5beta-Pregnane-3,20-dione + NADP+
   1.3.99  With unknown physiological acceptors
    1.3.99.6
     R02219  Progesterone + NADPH + H+ <=> 5beta-Pregnane-3,20-dione + NADP+
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.3.1.3
   R13168  3-Oxo-5beta-steroid <=> 3-Oxo-Delta4-steroid
    R02219  5beta-Pregnane-3,20-dione <=> Progesterone
Orthology
K00251  3-oxo-5-beta-steroid 4-dehydrogenase [EC:1.3.1.3]
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