KEGG   REACTION: R02838
Entry
R02838                      Reaction                               
Name
21-deoxycortisol,NADPH-hemoprotein reductase:oxygen oxidoreductase (21-hydroxylating)
Definition
21-Deoxycortisol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Cortisol + [Oxidized NADPH---hemoprotein reductase] + H2O
Equation
C05497 + C03024 + C00007 <=> C00735 + C03161 + C00001
Reaction class
RC00157  C00735_C05497
Enzyme
1.14.14.16
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.16
     R02838  21-Deoxycortisol + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Cortisol + [Oxidized NADPH---hemoprotein reductase] + H2O
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.14.14.16
   R02130  Steroid <=> 21-Hydroxysteroid
    R02838  21-Deoxycortisol <=> Cortisol
Orthology
K00513  steroid 21-monooxygenase [EC:1.14.14.16]
Reference
1  [PMID:13416221]
  Authors
RYAN KJ, ENGEL LL.
  Title
Hydroxylation of steroids at carbon 21.
  Journal
J Biol Chem 225:103-14 (1957)
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