KEGG   REACTION: R03697
Entry
R03697                      Reaction                               
Definition
Morphine + [Oxidized NADPH---hemoprotein reductase] + Formaldehyde + H2O <=> Codeine + [Reduced NADPH---hemoprotein reductase] + Oxygen
Equation
C01516 + C03161 + C00067 + C00001 <=> C06174 + C03024 + C00007
Comment
CYP2D6:O-demethylation
Reaction class
RC00392  C01516_C06174
RC01533  C00067_C06174
Enzyme
1.14.14.1
Pathway
rn00982  Drug metabolism - cytochrome P450
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1
     R03697  Morphine + [Oxidized NADPH---hemoprotein reductase] + Formaldehyde + H2O <=> Codeine + [Reduced NADPH---hemoprotein reductase] + Oxygen
Orthology
K17712  cytochrome P450 family 2 subfamily D6 [EC:1.14.14.1]
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