KEGG   REACTION: R03851
Entry
R03851                      Reaction                               
Name
11-deoxycorticosterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)
Definition
11-Deoxycorticosterone + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> Corticosterone + 2 Oxidized ferredoxin + H2O
Equation
C03205 + 2 C00138 + C00007 + 2 C00080 <=> C02140 + 2 C00139 + C00001
Reaction class
RC00661  C02140_C03205
Enzyme
1.14.15.4
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R03851  11-Deoxycorticosterone + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> Corticosterone + 2 Oxidized ferredoxin + H2O
Orthology
K00497  steroid 11beta-monooxygenase [EC:1.14.15.4]
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]
LinkDB

KEGG   REACTION: R03262
Entry
R03262                      Reaction                               
Name
corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)
Definition
Corticosterone + 2 Reduced adrenal ferredoxin + Oxygen + 2 H+ <=> 18-Hydroxycorticosterone + 2 Oxidized adrenal ferredoxin + H2O
Equation
C02140 + 2 C00662 + C00007 + 2 C00080 <=> C01124 + 2 C00667 + C00001
Reaction class
RC00257  C01124_C02140
Enzyme
1.14.15.4       1.14.15.5
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R03262  Corticosterone + 2 Reduced adrenal ferredoxin + Oxygen + 2 H+ <=> 18-Hydroxycorticosterone + 2 Oxidized adrenal ferredoxin + H2O
    1.14.15.5
     R03262  Corticosterone + 2 Reduced adrenal ferredoxin + Oxygen + 2 H+ <=> 18-Hydroxycorticosterone + 2 Oxidized adrenal ferredoxin + H2O
Orthology
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]
Other DBs
RHEA: 11875
LinkDB

KEGG   REACTION: R03263
Entry
R03263                      Reaction                               
Definition
18-Hydroxycorticosterone + Reduced adrenal ferredoxin + Oxygen <=> Aldosterone + Oxidized adrenal ferredoxin + 2 H2O
Equation
C01124 + C00662 + C00007 <=> C01780 + C00667 + 2 C00001
Reaction class
RC00893  C01124_C01780
Enzyme
1.14.15.4       1.14.15.5
Pathway
rn00140  Steroid hormone biosynthesis
rn01100  Metabolic pathways
Module
M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R03263  18-Hydroxycorticosterone + Reduced adrenal ferredoxin + Oxygen <=> Aldosterone + Oxidized adrenal ferredoxin + 2 H2O
    1.14.15.5
     R03263  18-Hydroxycorticosterone + Reduced adrenal ferredoxin + Oxygen <=> Aldosterone + Oxidized adrenal ferredoxin + 2 H2O
Orthology
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]
Reference
1  [PMID:21598279]
  Authors
Roumen L, Van Hoof B, Pieterse K, Hilbers PA, Custers EM, Plate R, De Gooyer M, Beugels IP, Emmen JM, Leysen D, Smits JF, Ottenheijm HC, Hermans JJ.
  Title
Application of a ligand-based theoretical approach to derive conversion paths and ligand conformations in CYP11B2-mediated aldosterone formation.
  Journal
J Comput Chem 32:2441-8 (2011)
DOI:10.1002/jcc.21827
Other DBs
RHEA: 50795
LinkDB

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