KEGG   REACTION: R04678
Entry
R04678                      Reaction                               
Name
16alpha-hydroxyandrost-4-ene-3,17-dione delta5-delat4-isomerase;
16alpha-hydroxydehydroepiandrosterone:NAD+ 3-oxidoreductase
Definition
16alpha-Hydroxyandrost-4-ene-3,17-dione + H+ + NADH <=> 16alpha-Hydroxydehydroepiandrosterone + NAD+
Equation
Comment
multi-step reaction (see R03176+R02644)
Reaction class
RC00001  C00003_C00004
RC00146  C05139_C05140
Enzyme
1.1.1.145       5.3.3.1
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145
     R04678  16alpha-Hydroxyandrost-4-ene-3,17-dione + H+ + NADH <=> 16alpha-Hydroxydehydroepiandrosterone + NAD+
 5. Isomerase reactions
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1
     R04678  16alpha-Hydroxyandrost-4-ene-3,17-dione + H+ + NADH <=> 16alpha-Hydroxydehydroepiandrosterone + NAD+
Orthology
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
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