KEGG   REACTION: R04850
Entry
R04850                      Reaction                               
Name
17alpha,21-dihydroxypregnenolone:oxygen oxidoreductase (11-hydroxylating)
Definition
17alpha,21-Dihydroxypregnenolone + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> 11beta,17alpha,21-Trihydroxypregnenolone + 2 Oxidized ferredoxin + H2O
Equation
C05487 + 2 C00138 + C00007 + 2 C00080 <=> C05489 + 2 C00139 + C00001
Comment
Oxidized ferredoxin is reduced by NADPH (see R01195)
Reaction class
RC00661  C05487_C05489
Enzyme
1.14.15.4
Pathway
rn00140  Steroid hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4
     R04850  17alpha,21-Dihydroxypregnenolone + 2 Reduced ferredoxin + Oxygen + 2 H+ <=> 11beta,17alpha,21-Trihydroxypregnenolone + 2 Oxidized ferredoxin + H2O
Orthology
K00497  steroid 11beta-monooxygenase [EC:1.14.15.4]
K07433  steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]
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